Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.99 Other carbon-carbon lyases
ID:4.1.99.14
Description:Spore photoproduct lyase.
Alternative Name: SP lyase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.99.14
BRENDA Enzyme Link: BRENDA 4.1.99.14
KEGG Enzyme Link: KEGG4.1.99.14
BioCyc Enzyme Link: BioCyc 4.1.99.14
ExPASy Enzyme Link: ExPASy4.1.99.14
EC2PDB Enzyme Link: EC2PDB 4.1.99.14
ExplorEnz Enzyme Link: ExplorEnz 4.1.99.14
PRIAM enzyme-specific profiles Link: PRIAM 4.1.99.14
IntEnz Enzyme Link: IntEnz 4.1.99.14
MEDLINE Enzyme Link: MEDLINE 4.1.99.14
MSA:

4.1.99.14;

Phylogenetic Tree:

4.1.99.14;

Uniprot:
M-CSA:
RHEA:56132 (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = thymidine dimer in DNA
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH2;+0:3]-[C;H0;+0:4](-[*:5])(-[CH2;+0:6]-[*:7])-[C;H0;+0:8](=[*:9])-[NH;+0:10]-[C;H0;+0:11]-1=[*:12]>>([*:7]-[CH3;+0:6].[*:1]-[n;H0;+0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[c;H0;+0:8](=[*:9]):[nH;+0:10]:[c;H0;+0:11]:1=[*:12])
Reaction
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References

TitleAuthorsDatePubMed ID
Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase.Silver SC, Chandra T, Zilinskas E, Ghose S, Broderick WE, Broderick JB2010 Aug20405152
Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct.Chandra T, Silver SC, Zilinskas E, Shepard EM, Broderick WE, Broderick JB2009 Feb 2519178276
Combined NMR and DFT studies for the absolute configuration elucidation of the spore photoproduct, a UV-induced DNA lesion.Mantel C, Chandor A, Gasparutto D, Douki T, Atta M, Fontecave M, Bayle PA, Mouesca JM, Bardet M2008 Dec 1719012397
Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates.Pieck JC, Hennecke U, Pierik AJ, Friedel MG, Carell T2006 Nov 2416968710
Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily.Buis JM, Cheek J, Kalliri E, Broderick JB2006 Sep 816829680
Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis.Chandor A, Berteau O, Douki T, Gasparutto D, Sanakis Y, Ollagnier-de-Choudens S, Atta M, Fontecave M2006 Sep 1516829676
The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion.Friedel MG, Berteau O, Pieck JC, Atta M, Ollagnier-de-Choudens S, Fontecave M, Carell T2006 Jan 2816493831
The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase.Rebeil R, Nicholson WL2001 Jul 3111470912