EC number:4.1.99.16
| ID: | 4.1.99.16 |
|---|---|
| Description: | Geosmin synthase. |
| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.99.16 |
| BRENDA Enzyme Link: | BRENDA 4.1.99.16 |
| KEGG Enzyme Link: | KEGG4.1.99.16 |
| BioCyc Enzyme Link: | BioCyc 4.1.99.16 |
| ExPASy Enzyme Link: | ExPASy4.1.99.16 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.99.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.99.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.99.16 |
| IntEnz Enzyme Link: | IntEnz 4.1.99.16 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.99.16 |
EC number:4.1.99.16
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:30459 | (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5]-[*:6]-[CH;+0:7](-[CH;+0:8]=[CH;+0:9]-[*:10])-[C;H0;+0:11](-[*:12])(-[*:13])-[OH;+0:14]>>[*:12]-[C;H0;+0:11](-[*:13])=[O;H0;+0:14].[*:1]-[CH2;+0:2]-[C;H0;+0:3]1(-[*:4])-[*:5]-[*:6]-[CH;+0:7]=[CH;+0:8]-[CH;+0:9]-1-[*:10] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. | Jiang J, He X, Cane DE | 2006 Jun 28 | 16787064 |
| Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. | Jiang J, He X, Cane DE | 2007 Nov | 17873868 |
| Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. | Cane DE, He X, Kobayashi S, Omura S, Ikeda H | 2006 Aug | 17080683 |
| RHEA:30455 | (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4](-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[CH2;+0:2]-[CH2;+0:3]-[C;H0;+0:4](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. | Jiang J, He X, Cane DE | 2006 Jun 28 | 16787064 |
| Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. | Jiang J, He X, Cane DE | 2007 Nov | 17873868 |
| Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. | Cane DE, He X, Kobayashi S, Omura S, Ikeda H | 2006 Aug | 17080683 |
| RHEA:30371 | (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5]-[*:6]-[CH;+0:7](-[CH;+0:8]=[CH;+0:9]-[*:10])-[C;H0;+0:11](-[*:12])(-[*:13])-[OH;+0:14].[OH2;+0:15]>>[*:12]-[C;H0;+0:11](-[*:13])=[O;H0;+0:14].[*:1]-[CH2;+0:2]-[C;H0;+0:3]1(-[*:4])-[*:5]-[*:6]-[CH2;+0:7]-[CH2;+0:8]-[C;H0;+0:9]-1(-[*:10])-[OH;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. | Jiang J, He X, Cane DE | 2006 Jun 28 | 16787064 |
| Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. | Jiang J, He X, Cane DE | 2007 Nov | 17873868 |
| Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. | Cane DE, He X, Kobayashi S, Omura S, Ikeda H | 2006 Aug | 17080683 |