EC number:4.1.99.17
| ID: | 4.1.99.17 |
|---|---|
| Description: | Phosphomethylpyrimidine synthase. |
| Cath: | 1.20.5.20; 1.20.5.2000; 3.20.20.540; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.99.17 |
| BRENDA Enzyme Link: | BRENDA 4.1.99.17 |
| KEGG Enzyme Link: | KEGG4.1.99.17 |
| BioCyc Enzyme Link: | BioCyc 4.1.99.17 |
| ExPASy Enzyme Link: | ExPASy4.1.99.17 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.99.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.99.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.99.17 |
| IntEnz Enzyme Link: | IntEnz 4.1.99.17 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.99.17 |
EC number:4.1.99.17
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24840 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[S+;H0:3](-[*:4])-[*:5].[*:6]-[CH;+0:7]1-[O;H0;+0:8]-[CH;+0:9](-[n;H0;+0:10]2:[cH;+0:11]:[n;H0;+0:12]:[cH;+0:13]:[*:14]:2-[NH2;+0:15])-[CH;+0:16](-[*:17])-[CH;+0:18]-1-[OH;+0:19]>>[*:1]-[CH3;+0:2].[*:17]-[CH;+0:16]=[O;H0;+0:19].[*:4]-[S;H0;+0:3]-[*:5].[*:6]-[c;H0;+0:7]1:[cH;+0:18]:[n;H0;+0:15]:[*:14](-[CH3;+0:13]):[n;H0;+0:10]:[c;H0;+0:11]:1-[NH2;+0:12].[C-;H0:9]#[O+;H0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase. | Chatterjee A, Hazra AB, Abdelwahed S, Hilmey DG, Begley TP | 2010 Nov 8 | 20886485 |
| Reaction of AdoMet with ThiC generates a backbone free radical. | Martinez-Gomez NC, Poyner RR, Mansoorabadi SO, Reed GH, Downs DM | 2009 Jan 20 | 19113839 |
| Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. | Chatterjee A, Li Y, Zhang Y, Grove TL, Lee M, Krebs C, Booker SJ, Begley TP, Ealick SE | 2008 Dec | 18953358 |
| ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. | Martinez-Gomez NC, Downs DM | 2008 Sep 2 | 18686975 |
| A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica. | Dougherty MJ, Downs DM | 2006 Aug | 16849799 |
| Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. | Lawhorn BG, Mehl RA, Begley TP | 2004 Sep 7 | 15326535 |