Enzyme

Download
EC Tree
     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.99 Other carbon-carbon lyases
ID:4.1.99.22
Description:GTP 3',8-cyclase.
Cath: 3.20.20.70;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.99.22
BRENDA Enzyme Link: BRENDA 4.1.99.22
KEGG Enzyme Link: KEGG4.1.99.22
BioCyc Enzyme Link: BioCyc 4.1.99.22
ExPASy Enzyme Link: ExPASy4.1.99.22
EC2PDB Enzyme Link: EC2PDB 4.1.99.22
ExplorEnz Enzyme Link: ExplorEnz 4.1.99.22
PRIAM enzyme-specific profiles Link: PRIAM 4.1.99.22
IntEnz Enzyme Link: IntEnz 4.1.99.22
MEDLINE Enzyme Link: MEDLINE 4.1.99.22
MSA:

4.1.99.22;

Phylogenetic Tree:

4.1.99.22;

Uniprot:
M-CSA:
RHEA:49576 AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[*:4]-[*:5]-[n;H0;+0:6]1:[*:7]:[*:8]:[n;H0;+0:9]:[cH;+0:10]:1.[*:11]-[S+;H0:12](-[*:13])-[CH2;+0:14]-[*:15]>>[*:1]-[C;H0;+0:2]1(-[*:3])-[*:4]-[*:5]-[N;H0;+0:6]2-[*:7]:[*:8]-[NH;+0:9]-[CH;+0:10]-2-1.[*:15]-[CH3;+0:14].[*:11]-[S;H0;+0:12]-[*:13]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis.Hover BM, Tonthat NK, Schumacher MA, Yokoyama K2015 May 1925941396
C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.Hover BM, Yokoyama K2015 Mar 1125697423
Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.Hover BM, Loksztejn A, Ribeiro AA, Yokoyama K2013 May 823627491
ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications.Lees NS, Hänzelmann P, Hernandez HL, Subramanian S, Schindelin H, Johnson MK, Hoffman BM2009 Jul 819566093
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.Hänzelmann P, Schindelin H2006 May 216632608
Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis.Hänzelmann P, Hernández HL, Menzel C, García-Serres R, Huynh BH, Johnson MK, Mendel RR, Schindelin H2004 Aug 1315180982
Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors.Rieder C, Eisenreich W, O'Brien J, Richter G, Götze E, Boyle P, Blanchard S, Bacher A, Simon H1998 Jul 19692897
Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies.Wuebbens MM, Rajagopalan KV1995 Jan 207836363
Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.Hänzelmann P, Schindelin H2004 Aug 3115317939
The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor.Santamaria-Araujo JA, Fischer B, Otte T, Nimtz M, Mendel RR, Wray V, Schwarz G2004 Apr 1614761975