EC number:4.2.1.1
3D structure
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1EKJ;
1KOQ;
1KOP;
3ZNC;
2ZNC;
5KU6;
5JNC;
5JNA;
5JN9;
5JN8;
5IPZ;
3F7U;
3FW3;
3F7B;
1ZNC;
1FLJ;
6HWZ;
6G3V;
6FAG;
6FAF;
6F3B;
6EX1;
6EVR;
5GMM;
5E2M;
4WUQ;
4WUP;
4WR7;
3W6I;
3W6H;
3LXE;
2NN7;
2NN1;
2NMX;
2IT4;
2FW4;
2FOY;
1JV0;
1J9W;
2CAB;
1HUH;
1HUG;
1HCB;
1CRM;
1BZM;
1AZM;
1RJ6;
1RJ5;
1KEQ;
1DMY;
1DMX;
1URT;
5L9E;
4QIY;
1XEV;
6H6S;
5OGN;
5LVS;
5LL4;
5L70;
5L6T;
5L6K;
5L3O;
5DOH;
4LP6;
3MWO;
1FSR;
1FSQ;
1FSN;
1FR7;
9CA2;
8CA2;
7CA2;
6QEB;
6MBY;
6MBV;
6IC2;
6H34;
6H33;
6H2Z;
6H29;
6GXE;
6GXB;
6GOT;
6GDC;
6GCY;
6G6T;
6G3Q;
6FJJ;
6FJI;
6EQU;
6EEO;
6EEH;
6EEA;
6EDA;
6ECZ;
6EBE;
6E92;
6E91;
6E8X;
6E8P;
6D1M;
6D1L;
6CJV;
6CEH;
6CA2;
6C7X;
6C7W;
6BC9;
6BBS;
6B5A;
6B59;
6B4D;
5ZXW;
5YUK;
5YUJ;
5YUI;
5Y2S;
5Y2R;
5WLV;
5WLU;
5WLT;
5WLR;
5WG7;
5WEX;
5W8B;
5VGY;
5UMC;
5ULN;
5U0G;
5U0F;
5U0E;
5U0D;
5TYA;
5TY9;
5TY8;
5TY1;
5TXY;
5TI0;
5THN;
5THJ;
5THI;
5TH4;
5TFX;
5T75;
5T74;
5T72;
5T71;
5SZ7;
5SZ6;
5SZ5;
5SZ4;
5SZ3;
5SZ2;
5SZ0;
5OGP;
5OGO;
5O07;
5NYA;
5NY6;
5NY3;
5NY1;
5NXW;
5NXV;
5NXP;
5NXO;
5NXM;
5NXI;
5NXG;
5NEE;
5NEA;
5N25;
5N24;
5N1S;
5N1R;
5N0E;
5N0D;
5MJN;
5M78;
5LMD;
5LLH;
5LLG;
5LLE;
5LLC;
5LL8;
5LJT;
5LJQ;
5JQT;
5JQ0;
5JN7;
5JN3;
5JN1;
5JMZ;
5JGT;
5JGS;
5JG5;
5JG3;
5JES;
5JEP;
5JEH;
5JEG;
5JE7;
5JDV;
5J8Z;
5GMN;
5G0C;
5G0B;
5G03;
5FNM;
5FNL;
5FNK;
5FNJ;
5FNI;
5FNH;
5FNG;
5FLT;
5FLS;
5FLR;
5FLQ;
5FLP;
5FLO;
5FDI;
5FDC;
5EOI;
5EKM;
5EKJ;
5EKH;
5EIJ;
5EHW;
5EHV;
5EHE;
5EH8;
5EH7;
5EH5;
5E2S;
5E2R;
5E2K;
5E28;
5DSR;
5DSQ;
5DSP;
5DSO;
5DSM;
5DSL;
5DSK;
5DRS;
5DOG;
5CLU;
5CAC;
5CA2;
5C8I;
5BYI;
5BRW;
5BRV;
5BRU;
5BNL;
5AML;
5AMG;
5AMD;
5A6H;
4ZX1;
4ZX0;
4ZWZ;
4ZWY;
4ZWX;
4ZWI;
4ZAO;
4Z1N;
4Z1K;
4Z1J;
4Z1E;
4Z0Q;
4YYT;
4YXU;
4YXO;
4YXI;
4YX4;
4YWP;
4YVY;
4YGN;
4YGL;
4YGK;
4YGJ;
4Y0J;
4XE1;
4WW6;
4WL4;
4RUZ;
4RUY;
4RUX;
4RN4;
4RIV;
4RIU;
4RH2;
4RFD;
4RFC;
4R5B;
4R5A;
4R59;
4QY3;
4QTL;
4QSI;
4QSB;
4QSA;
4QK3;
4QK2;
4QK1;
4QJM;
4QEF;
4Q9Y;
4Q99;
4Q90;
4Q8Z;
4Q8Y;
4Q8X;
4Q87;
4Q83;
4Q81;
4Q7W;
4Q7V;
4Q7S;
4Q7P;
4Q78;
4Q6E;
4Q6D;
4Q49;
4Q09;
4Q08;
4Q07;
4Q06;
4PZH;
4PYY;
4PYX;
4PXX;
4PQ7;
4N16;
4N0X;
4MO8;
4MLX;
4MLT;
4MDM;
4MDL;
4MDG;
4M2W;
4M2V;
4M2U;
4M2R;
4LHI;
4L5W;
4L5V;
4L5U;
4KV0;
4KUY;
4KUW;
4KUV;
4KNJ;
4KNI;
4KAP;
4K1Q;
4K13;
4K0Z;
4K0T;
4K0S;
4JSZ;
4JSW;
4JSS;
4JSA;
4JS6;
4IWZ;
4ITP;
4ITO;
4ILX;
4IDR;
4HT0;
4HF3;
4HEZ;
4HEY;
4HEW;
4HBA;
4GL1;
4G0C;
4FVO;
4FVN;
4FU5;
4FRC;
4FPT;
4FL7;
4FIK;
4E5Q;
4E4A;
4E49;
4E3H;
4E3G;
4E3F;
4E3D;
4DZ9;
4DZ7;
4CQ0;
4CAC;
4BF6;
4BF1;
4BCW;
3ZP9;
3VBD;
3V7X;
3V5G;
3V3J;
3V3I;
3V3H;
3V3G;
3V3F;
3V2M;
3V2J;
3U7C;
3U47;
3U45;
3U3A;
3TVO;
3TVN;
3TMJ;
3T85;
3T84;
3T83;
3T82;
3T5Z;
3T5U;
3SBI;
3SBH;
3SAX;
3SAP;
3S9T;
3S8X;
3S78;
3S77;
3S76;
3S75;
3S74;
3S73;
3S72;
3S71;
3RZ8;
3RZ7;
3RZ5;
3RZ1;
3RZ0;
3RYZ;
3RYY;
3RYX;
3RYV;
3RYJ;
3RLD;
3RJ7;
3RGE;
3RG4;
3RG3;
3R17;
3R16;
3QYK;
3PYK;
3PO6;
3PJJ;
3P5L;
3P5A;
3P58;
3P55;
3P4V;
3P44;
3P3J;
3P3H;
3OYS;
3OYQ;
3OY0;
3OKV;
3OKU;
3OIM;
3OIL;
3OIK;
3NJ9;
3NI5;
3NB5;
3N4B;
3N3J;
3N2P;
3N0N;
3MZC;
3MYQ;
3MNU;
3MNK;
3MNJ;
3MNI;
3MNA;
3MMF;
3ML2;
3MHO;
3MHM;
3MHL;
3MHI;
3MHC;
3M98;
3M96;
3M67;
3M5T;
3M5S;
3M5E;
3M40;
3M3X;
3M2Z;
3M2Y;
3M2X;
3M2N;
3M1W;
3M1Q;
3M1K;
3M1J;
3M14;
3M04;
3L14;
3KWA;
3KS3;
3KON;
3KOK;
3KOI;
3KNE;
3KKX;
3KIG;
3K7K;
3K34;
3K2F;
3IGP;
3IEO;
3IBU;
3IBN;
3IBL;
3IBI;
3HS4;
3HLJ;
3HKU;
3HKT;
3HKQ;
3HKN;
3HFP;
3GZ0;
3FFP;
3F8E;
3F4X;
3EFT;
3DVD;
3DVC;
3DVB;
3DV7;
3DD8;
3DD0;
3DCW;
3DCS;
3DCC;
3DC9;
3DC3;
3DBU;
3DAZ;
3D9Z;
3D93;
3D92;
3D8W;
3CYU;
3CAJ;
3CA2;
3C7P;
3BL1;
3BL0;
3BET;
3B4F;
2X7U;
2X7T;
2X7S;
2WEO;
2WEJ;
2WEH;
2WEG;
2WD3;
2WD2;
2VVB;
2VVA;
2QP6;
2QOA;
2QO8;
2Q38;
2Q1Q;
2Q1B;
2POW;
2POV;
2POU;
2OSM;
2OSF;
2O4Z;
2NXT;
2NXS;
2NXR;
2NWZ;
2NWY;
2NWP;
2NWO;
2NNV;
2NNS;
2NNO;
2NNG;
2ILI;
2HOC;
2HNC;
2HL4;
2HKK;
2HD6;
2H4N;
2H15;
2GEH;
2GD8;
2FOV;
2FOU;
2FOS;
2FOQ;
2FNN;
2FNM;
2FNK;
2FMZ;
2FMG;
2F14;
2EZ7;
2EU3;
2EU2;
2CBE;
2CBD;
2CBC;
2CBB;
2CBA;
2CA2;
2AX2;
2AW1;
2ABE;
1ZSC;
1ZSB;
1ZSA;
1ZH9;
1ZGF;
1ZGE;
1ZFQ;
1ZFK;
1ZE8;
1Z9Y;
1YO2;
1YO1;
1YO0;
1YDD;
1YDC;
1YDB;
1YDA;
1XQ0;
1XPZ;
1XEG;
1UGG;
1UGF;
1UGE;
1UGD;
1UGC;
1UGB;
1UGA;
1TTM;
1THK;
1TH9;
1TG9;
1TG3;
1TEU;
1TEQ;
1TE3;
1TBT;
1TB0;
1T9N;
1RZE;
1RZD;
1RZC;
1RZB;
1RZA;
1RAZ;
1RAY;
1OQ5;
1OKN;
1OKM;
1OKL;
1MUA;
1MOO;
1LZV;
1LUG;
1LGD;
1LG6;
1LG5;
1KWR;
1KWQ;
1IF9;
1IF8;
1IF7;
1IF6;
1IF5;
1IF4;
1I9Q;
1I9P;
1I9O;
1I9N;
1I9M;
1I9L;
1I91;
1I90;
1I8Z;
1HVA;
1HED;
1HEC;
1HEB;
1HEA;
1HCA;
1H9Q;
1H9N;
1H4N;
1G54;
1G53;
1G52;
1G4O;
1G4J;
1G48;
1G46;
1G45;
1G3Z;
1G1D;
1G0F;
1G0E;
1FR4;
1FQR;
1FQM;
1FQL;
1F2W;
1EOU;
1DCB;
1DCA;
1CVH;
1CVF;
1CVE;
1CVD;
1CVC;
1CVB;
1CVA;
1CRA;
1CNY;
1CNX;
1CNW;
1CNJ;
1CNI;
1CNH;
1CNG;
1CNC;
1CNB;
1CIN;
1CIM;
1CIL;
1CCU;
1CCT;
1CCS;
1CAZ;
1CAY;
1CAO;
1CAN;
1CAM;
1CAL;
1CAK;
1CAJ;
1CAI;
1CAH;
1CA3;
1CA2;
1BV3;
1BNW;
1BNV;
1BNU;
1BNT;
1BNQ;
1BNN;
1BNM;
1BN4;
1BN3;
1BN1;
1BIC;
1BCD;
1AVN;
1AM6;
1A42;
12CA;
4CNR;
5A25;
4CNW;
1V9E;
5EZT;
4CNX;
4CNV;
1V9I;
1G6V;
6G7A;
6G5L;
5MSB;
5MSA;
5LLP;
5LLO;
5LL9;
5LL5;
4WW8;
4QJW;
4QJO;
4QJ0;
4Q0L;
4KP8;
4KP5;
4HT2;
1JD0;
1T75;
2ESF;
1I6O;
1I6P;
5G01;
6HX5;
6H38;
6H37;
6H36;
6GWU;
6G9U;
6G98;
6G5U;
6G4T;
6FE2;
6FE1;
6FE0;
6BCC;
5WGP;
5SZ1;
5SWC;
5OHH;
5OGJ;
5LLN;
5LLA;
5FL6;
5FL5;
5FL4;
5E5U;
5E5R;
5E2N;
5DVX;
5CJF;
4WAM;
4WAK;
4WAJ;
4QSJ;
4QJX;
4QJP;
4QIZ;
4MTY;
4LU3;
4KNN;
4KNM;
4HU1;
4CA2;
3UYQ;
3UYN;
3S97;
3MNH;
3ML5;
3MF3;
3MDZ;
3KLD;
3JXH;
3JXG;
3JXF;
3IAI;
3FE4;
3EYX;
3EFI;
3E3I;
3E3G;
3E3F;
3E31;
3E2X;
3E2W;
3E2A;
3E28;
3E24;
3E1W;
3E1V;
3DA2;
3D0N;
3CZV;
3B1B;
2W2J;
2HFW;
2A8D;
2A8C;
2A5V;
1Z97;
1Z93;
1YM3;
1JCZ;
1FQN;
1CZM;
1CNK;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.1 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.1 |
| KEGG Enzyme Link: | KEGG4.2.1.1 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.1 |
| ExPASy Enzyme Link: | ExPASy4.2.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.1 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.1 |
| RHEA:10748 | H(+) + hydrogencarbonate = CO2 + H2O |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[OH;+0:4].[H+;H0:5]>>[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[OH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide. | Huang S, Xue Y, Sauer-Eriksson E, Chirica L, Lindskog S, Jonsson BH | 1998 | 9761692 |
| Structure and mechanism of carbonic anhydrase. | Lindskog S | 1997 | 9336012 |
| Refined structure of human carbonic anhydrase II at 2.0 A resolution. | Eriksson AE, Jones TA, Liljas A | 1988 | 3151019 |
| Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant. | Tu CK, Silverman DN, Forsman C, Jonsson BH, Lindskog S | 1989 Sep 19 | 2514797 |
| Importance of post-translational modifications for functionality of a chloroplast-localized carbonic anhydrase (CAH1) in Arabidopsis thaliana. | Burén S, Ortega-Villasante C, Blanco-Rivero A, Martínez-Bernardini A, Shutova T, Shevela D, Messinger J, Bako L, Villarejo A, Samuelsson G | 2011 | 21695217 |
| Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. | Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R | 2005 Feb 1 | 15667203 |
| Carbonic anhydrase inhibitors. | Supuran CT, Scozzafava A, Casini A | 2003 Mar | 12500287 |
| Prokaryotic carbonic anhydrases. | Smith KS, Ferry JG | 2000 Oct | 10978542 |
| Tobacco Nectarin III is a bifunctional enzyme with monodehydroascorbate reductase and carbonic anhydrase activities. | Carter CJ, Thornburg RW | 2004 Feb | 15284496 |