EC number:4.2.1.116
| ID: | 4.2.1.116 | ||
|---|---|---|---|
| Description: | 3-hydroxypropionyl-CoA dehydratase. | ||
| Alternative Name: |
3-hydroxypropionyl-CoA hydro-lyase. 3-hydroxypropanoate-CoA dehydratase. | ||
| Prosite: | PDOC00150; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.116 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.116 |
| KEGG Enzyme Link: | KEGG4.2.1.116 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.116 |
| ExPASy Enzyme Link: | ExPASy4.2.1.116 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.116 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.116 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.116 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.116 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.116 |
EC number:4.2.1.116
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:26558 | (3S)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2. | Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A | 2010 Jul 30 | 20463021 |
| 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales. | Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G | 2009 Jul | 19429610 |
| Effect of mutagenesis on the stereochemistry of enoyl-CoA hydratase. | Feng Y, Hofstein HA, Zwahlen J, Tonge PJ | 2002 Oct 22 | 12379132 |
| RHEA:26518 | 3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[OH;+0:4]>>[*:1]-[CH;+0:2]=[CH2;+0:3].[OH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. | Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N | 2015 Oct | 26251176 |
| 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales. | Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G | 2009 Jul | 19429610 |
| A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea. | Berg IA, Kockelkorn D, Buckel W, Fuchs G | 2007 Dec 14 | 18079405 |