EC number:4.2.1.119

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.119
Description:Enoyl-CoA hydratase 2.
Alternative Name: ECH2.
D-specific 2-trans-enoyl-CoA hydratase.
D-3-hydroxyacyl-CoA hydro-lyase.
2-enoyl-CoA hydratase 2.
Cath: 3.30.1050.10; 3.30.160.260; 3.40.50.720; 3.10.129.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.119
BRENDA Enzyme Link: BRENDA 4.2.1.119
KEGG Enzyme Link: KEGG4.2.1.119
BioCyc Enzyme Link: BioCyc 4.2.1.119
ExPASy Enzyme Link: ExPASy4.2.1.119
EC2PDB Enzyme Link: EC2PDB 4.2.1.119
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.119
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.119
IntEnz Enzyme Link: IntEnz 4.2.1.119
MEDLINE Enzyme Link: MEDLINE 4.2.1.119

EC number:4.2.1.119

MSA:

4.2.1.119;
Phylogenetic Tree:

4.2.1.119;
Uniprot:
M-CSA:
RHEA:26526 a (3R)-hydroxyacyl-CoA = a (2E)-enoyl CoA + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:4]-[*:5].[OH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae.Fukui T, Shiomi N, Doi Y1998 Feb9457873
Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA.Engeland K, Kindl H1991 Aug 151879422
Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana.Goepfert S, Hiltunen JK, Poirier Y2006 Nov 2416982622
Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.Koski KM, Haapalainen AM, Hiltunen JK, Glumoff T2005 Feb 415644212