EnzyMine

Download

EC Tree

4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:	4.2.1.120
Description:	4-hydroxybutanoyl-CoA dehydratase.
Cath:	1.10.3140.10; 1.20.140.10; 2.40.110.10;

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 4.2.1.120
BRENDA Enzyme Link:	BRENDA 4.2.1.120
KEGG Enzyme Link:	KEGG4.2.1.120
BioCyc Enzyme Link:	BioCyc 4.2.1.120
ExPASy Enzyme Link:	ExPASy4.2.1.120
EC2PDB Enzyme Link:	EC2PDB 4.2.1.120
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.120
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.120
IntEnz Enzyme Link:	IntEnz 4.2.1.120
MEDLINE Enzyme Link:	MEDLINE 4.2.1.120

RHEA:26530	4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O
RULE(radius=1)	[:1]-[CH2;+0:2]-[CH2;+0:3]-[CH2;+0:4]-[OH;+0:5]>>[:1]-[CH;+0:2]=[CH;+0:3]-[CH3;+0:4].[OH2;+0:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin.	Martins BM, Dobbek H, Cinkaya I, Buckel W, Messerschmidt A	2004 Nov 2	15496473
4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction.	Müh U, Cinkaya I, Albracht SP, Buckel W	1996 Sep 10	8794752
Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase from Clostridium aminobutyricum.	Scherf U, Buckel W	1993 Jul 15	8344309
Assay of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum.	Willadsen P, Buckel W	1990 Jul	2227355
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.	Berg IA, Kockelkorn D, Buckel W, Fuchs G	2007 Dec 14	18079405