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4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:	4.2.1.123
Description:	Tetrahymanol synthase.
Alternative Name:	Squalene--tetrahymanol cyclase.

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UniProtKB Enzyme Link:	UniProtKB 4.2.1.123
BRENDA Enzyme Link:	BRENDA 4.2.1.123
KEGG Enzyme Link:	KEGG4.2.1.123
BioCyc Enzyme Link:	BioCyc 4.2.1.123
ExPASy Enzyme Link:	ExPASy4.2.1.123
EC2PDB Enzyme Link:	EC2PDB 4.2.1.123
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.123
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.123
IntEnz Enzyme Link:	IntEnz 4.2.1.123
MEDLINE Enzyme Link:	MEDLINE 4.2.1.123

RHEA:30675	tetrahymanol = H2O + squalene
RULE(radius=1)	[:1]-[C;H0;+0:2]12-[:3]-[:4]-[CH;+0:5]3-[C;H0;+0:6](-[:7])(-[:8])-[CH;+0:9](-[OH;+0:10])-[:11]-[:12]-[C;H0;+0:13]-3(-[:14])-[CH;+0:15]-1-[:16]-[:17]-[CH;+0:18]1-[C;H0;+0:19]3(-[:20])-[:21]-[:22]-[CH2;+0:23]-[C;H0;+0:24](-[:25])(-[:26])-[CH;+0:27]-3-[:28]-[:29]-[C;H0;+0:30]-1-2-[:31]>>[:1]-[C;H0;+0:2](-[:3]-[:4]-[CH;+0:5]=[C;H0;+0:13](-[:14])-[:12]-[:11]-[CH;+0:9]=[C;H0;+0:6](-[:7])-[:8])=[CH;+0:15]-[:16]-[:17]-[CH;+0:18]=[C;H0;+0:30](-[:31])-[:29]-[:28]-[CH;+0:27]=[C;H0;+0:19](-[:20])-[:21]-[:22]-[CH;+0:23]=[C;H0;+0:24](-[:25])-[:26].[OH2;+0:10]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila.	Saar J, Kader JC, Poralla K, Ourisson G	1991 Sep 2	1892870
Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis.	Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D	2005 Jun 28	15959594