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4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:	4.2.1.125
Description:	Dammarenediol II synthase.
Alternative Name:	Dammarenediol synthase. 2,3-oxidosqualene (20S)-dammarenediol cyclase.

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UniProtKB Enzyme Link:	UniProtKB 4.2.1.125
BRENDA Enzyme Link:	BRENDA 4.2.1.125
KEGG Enzyme Link:	KEGG4.2.1.125
BioCyc Enzyme Link:	BioCyc 4.2.1.125
ExPASy Enzyme Link:	ExPASy4.2.1.125
EC2PDB Enzyme Link:	EC2PDB 4.2.1.125
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.125
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.125
IntEnz Enzyme Link:	IntEnz 4.2.1.125
MEDLINE Enzyme Link:	MEDLINE 4.2.1.125

RHEA:30855	dammarenediol-II = (S)-2,3-epoxysqualene + H2O
RULE(radius=1)	([:1]-[C;H0;+0:2](-[:3]-[:4]-[CH;+0:5]=[C;H0;+0:6](-[:7])-[:8])=[CH;+0:9]-[:10]-[:11]-[CH;+0:12]=[C;H0;+0:13](-[:14])-[:15]-[:16]-[CH;+0:17]=[C;H0;+0:18](-[:19])-[:20].[:21]-[C;H0;+0:22]1(-[:23])-[:24]-[O;H0;+0:25]-1).[OH2;+0:26]>>[:1]-[C;H0;+0:2]12-[:3]-[:4]-[CH;+0:5](-[C;H0;+0:6](-[:7])(-[:8])-[OH;+0:26])-[CH;+0:9]-1-[:10]-[:11]-[CH;+0:12]1-[C;H0;+0:18](-[:19])(-[:20])-[CH;+0:17](-[C;H0;+0:22](-[:21])(-[:23])-[:24]-[OH;+0:25])-[:16]-[:15]-[C;H0;+0:13]-1-2-[:14]
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Title	Authors	Date	PubMed ID
Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng.	Han JY, Kwon YS, Yang DC, Jung YR, Choi YE	2006 Dec	17088293
Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng.	Tansakul P, Shibuya M, Kushiro T, Ebizuka Y	2006 Oct 2	16962103