EC number:4.2.1.126

Enzyme

Download
EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.126
Description:N-acetylmuramic acid 6-phosphate etherase.
Alternative Name: MurNAc-6-P etherase.
Cath: 1.10.8.10; 1.10.8.1080; 3.30.420.40; 3.40.50.10490;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.126
BRENDA Enzyme Link: BRENDA 4.2.1.126
KEGG Enzyme Link: KEGG4.2.1.126
BioCyc Enzyme Link: BioCyc 4.2.1.126
ExPASy Enzyme Link: ExPASy4.2.1.126
EC2PDB Enzyme Link: EC2PDB 4.2.1.126
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.126
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.126
IntEnz Enzyme Link: IntEnz 4.2.1.126
MEDLINE Enzyme Link: MEDLINE 4.2.1.126

EC number:4.2.1.126

MSA:

4.2.1.126;
Phylogenetic Tree:

4.2.1.126;
Uniprot:
M-CSA:
RHEA:26410 H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling.Hadi T, Dahl U, Mayer C, Tanner ME2008 Nov 418837509
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT2006 Feb16452451
Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase".Jaeger T, Arsic M, Mayer C2005 Aug 2615983044
Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate.Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT2005 Jun15901686