EC number:4.2.1.129

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.129
Description:Squalene--hopanol cyclase.
Alternative Name: Squalene--hopene cyclase.
Cath: 1.50.10.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.129
BRENDA Enzyme Link: BRENDA 4.2.1.129
KEGG Enzyme Link: KEGG4.2.1.129
BioCyc Enzyme Link: BioCyc 4.2.1.129
ExPASy Enzyme Link: ExPASy4.2.1.129
EC2PDB Enzyme Link: EC2PDB 4.2.1.129
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.129
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.129
IntEnz Enzyme Link: IntEnz 4.2.1.129
MEDLINE Enzyme Link: MEDLINE 4.2.1.129

EC number:4.2.1.129

MSA:

4.2.1.129;
Phylogenetic Tree:

4.2.1.129;
Uniprot:
M-CSA:
RHEA:16561 H2O + squalene = hopan-22-ol
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8]-[*:9]-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[*:13])=[CH;+0:14]-[*:15]-[*:16]-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[*:20]-[*:21]-[CH;+0:22]=[C;H0;+0:23](-[*:24])-[*:25]-[*:26]-[CH;+0:27]=[C;H0;+0:28](-[*:29])-[*:30].[OH2;+0:31]>>[*:1]-[C;H0;+0:2]12-[*:3]-[*:4]-[CH;+0:5]3-[C;H0;+0:6](-[*:7])(-[*:8]-[*:9]-[CH2;+0:10]-[C;H0;+0:11]-3(-[*:12])-[*:13])-[CH;+0:14]-1-[*:15]-[*:16]-[CH;+0:17]1-[C;H0;+0:18]-2(-[*:19])-[*:20]-[*:21]-[CH;+0:22]2-[CH;+0:27](-[C;H0;+0:28](-[*:29])(-[*:30])-[OH;+0:31])-[*:26]-[*:25]-[C;H0;+0:23]-1-2-[*:24]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Squalene-hopene cyclases.Siedenburg G, Jendrossek D2011 Jun21531832
Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A2004 May 2115136801
Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.Sato T, Kouda M, Hoshino T2004 Mar15056909