EC number:4.2.1.140

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.140
Description:Gluconate/galactonate dehydratase.
Alternative Name: Gluconate dehydratase.
Cath: 3.20.20.120; 3.30.390.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.140
BRENDA Enzyme Link: BRENDA 4.2.1.140
KEGG Enzyme Link: KEGG4.2.1.140
BioCyc Enzyme Link: BioCyc 4.2.1.140
ExPASy Enzyme Link: ExPASy4.2.1.140
EC2PDB Enzyme Link: EC2PDB 4.2.1.140
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.140
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.140
IntEnz Enzyme Link: IntEnz 4.2.1.140
MEDLINE Enzyme Link: MEDLINE 4.2.1.140

EC number:4.2.1.140

MSA:

4.2.1.140;
Phylogenetic Tree:

4.2.1.140;
Uniprot:
M-CSA:
RHEA:21612 D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[CH2;+0:4]-[*:5].[OH2;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.Reher M, Fuhrer T, Bott M, Schönheit P2010 Feb20023024
The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum.Andreesen JR, Gottschalk G19695383859
Purification and properties of D-gluconate dehydratase from Clostridium pasteurianum.Bender R, Gottschalk G1973 Dec 34772682
RHEA:18649 D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[CH2;+0:4]-[*:5].[OH2;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.Reher M, Fuhrer T, Bott M, Schönheit P2010 Feb20023024
Gluconate dehydratase from the promiscuous Entner-Doudoroff pathway in Sulfolobus solfataricus.Lamble HJ, Milburn CC, Taylor GL, Hough DW, Danson MJ2004 Oct 815474024
The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation.Ahmed H, Ettema TJ, Tjaden B, Geerling AC, van der Oost J, Siebers B2005 Sep 115869466