EC number:4.2.1.147

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.147
Description:5,6,7,8-tetrahydromethanopterin hydro-lyase.
Alternative Name: Formaldehyde-activating enzyme.
Cath: 3.30.230.60;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.147
BRENDA Enzyme Link: BRENDA 4.2.1.147
KEGG Enzyme Link: KEGG4.2.1.147
BioCyc Enzyme Link: BioCyc 4.2.1.147
ExPASy Enzyme Link: ExPASy4.2.1.147
EC2PDB Enzyme Link: EC2PDB 4.2.1.147
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.147
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.147
IntEnz Enzyme Link: IntEnz 4.2.1.147
MEDLINE Enzyme Link: MEDLINE 4.2.1.147

EC number:4.2.1.147

MSA:

4.2.1.147;
Phylogenetic Tree:

4.2.1.147;
Uniprot:
M-CSA:
RHEA:24678 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
RULE(radius=1) [*:1]-[NH;+0:2]-[*:3]-[*:4]-[NH;+0:5]-[*:6].[CH2;+0:7]=[O;H0;+0:8]>>[*:1]-[N;H0;+0:2]1-[*:3]-[*:4]-[N;H0;+0:5](-[*:6])-[CH2;+0:7]-1.[OH2;+0:8]
Reaction
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References

TitleAuthorsDatePubMed ID
Liver resections: complications and survival outcome.Grazi GL2007 Jun20528313
How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1.Acharya P, Goenrich M, Hagemeier CH, Demmer U, Vorholt JA, Thauer RK, Ermler U2005 Apr 815632161