EC number:4.2.1.152

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.152
Description:Hydroperoxy icosatetraenoate dehydratase.
Alternative Name: Epidermal lipoxygenase-3.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.152
BRENDA Enzyme Link: BRENDA 4.2.1.152
KEGG Enzyme Link: KEGG4.2.1.152
BioCyc Enzyme Link: BioCyc 4.2.1.152
ExPASy Enzyme Link: ExPASy4.2.1.152
EC2PDB Enzyme Link: EC2PDB 4.2.1.152
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.152
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.152
IntEnz Enzyme Link: IntEnz 4.2.1.152
MEDLINE Enzyme Link: MEDLINE 4.2.1.152

EC number:4.2.1.152

MSA:

4.2.1.152;
Phylogenetic Tree:

4.2.1.152;
Uniprot:
M-CSA:
RHEA:37927 (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[OH;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[OH2;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.Yu Z, Schneider C, Boeglin WE, Brash AR2006 Nov 1517045234
RHEA:37935 (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[OH;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[OH2;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.Yu Z, Schneider C, Boeglin WE, Brash AR2006 Nov 1517045234
RHEA:37943 (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[OH;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[OH2;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR2003 Aug 512881489
RHEA:37947 (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[OH;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[OH2;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR2003 Aug 512881489
RHEA:55556 a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O
RULE(radius=1)
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.Zheng Y, Yin H, Boeglin WE, Elias PM, Crumrine D, Beier DR, Brash AR2011 Jul 821558561
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.Zheng Y, Brash AR2010 Dec 1720921226
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.Yu Z, Schneider C, Boeglin WE, Brash AR2006 Nov 1517045234
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR2003 Aug 512881489
On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.Zheng Y, Brash AR2010 Dec 1720923767