EC number:4.2.1.157

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.157
Description:(R)-2-hydroxyisocaproyl-CoA dehydratase.
Alternative Name: 2-hydroxyisocaproyl-CoA dehydratase.
Cath: 1.20.1270.370; 3.40.50.11890; 3.40.50.11900;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.157
BRENDA Enzyme Link: BRENDA 4.2.1.157
KEGG Enzyme Link: KEGG4.2.1.157
BioCyc Enzyme Link: BioCyc 4.2.1.157
ExPASy Enzyme Link: ExPASy4.2.1.157
EC2PDB Enzyme Link: EC2PDB 4.2.1.157
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.157
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.157
IntEnz Enzyme Link: IntEnz 4.2.1.157
MEDLINE Enzyme Link: MEDLINE 4.2.1.157

EC number:4.2.1.157

MSA:

4.2.1.157;
Phylogenetic Tree:

4.2.1.157;
Uniprot:
M-CSA:
RHEA:46924 (R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O
RULE(radius=1) [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:4]-[*:5].[OH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase.Knauer SH, Buckel W, Dobbek H2011 Mar 3021366233
2-Hydroxyisocaproyl-CoA dehydratase and its activator from Clostridium difficile.Kim J, Darley D, Buckel W2005 Jan15654892