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4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:	4.2.1.167
Description:	(R)-2-hydroxyglutaryl-CoA dehydratase.

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UniProtKB Enzyme Link:	UniProtKB 4.2.1.167
BRENDA Enzyme Link:	BRENDA 4.2.1.167
KEGG Enzyme Link:	KEGG4.2.1.167
BioCyc Enzyme Link:	BioCyc 4.2.1.167
ExPASy Enzyme Link:	ExPASy4.2.1.167
EC2PDB Enzyme Link:	EC2PDB 4.2.1.167
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.167
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.167
IntEnz Enzyme Link:	IntEnz 4.2.1.167
MEDLINE Enzyme Link:	MEDLINE 4.2.1.167

RHEA:42448	(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
RULE(radius=1)	[:1]-[CH2;+0:2]-[CH;+0:3](-[:4])-[OH;+0:5]>>[:1]-[CH;+0:2]=[CH;+0:3]-[:4].[OH2;+0:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Activation of (R)-2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans.	Müller U, Buckel W	1995 Jun 1	7607244
The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate.	Buckel W	1980 May	7398622
Purification of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. An iron-sulfur protein.	Schweiger G, Dutscho R, Buckel W	1987 Dec 1	3691501
Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid.	Parthasarathy A, Pierik AJ, Kahnt J, Zelder O, Buckel W	2011 May 3	21434666
Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.	Locher KP, Hans M, Yeh AP, Schmid B, Buckel W, Rees DC	2001 Mar 16	11243821
2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.	Hans M, Sievers J, Müller U, Bill E, Vorholt JA, Linder D, Buckel W	1999 Oct 1	10491198