EC number:4.2.1.17
| ID: | 4.2.1.17 | ||
|---|---|---|---|
| Description: | Enoyl-CoA hydratase. | ||
| Alternative Name: |
Unsaturated acyl-CoA hydratase. Enoyl hydrase. | ||
| Prosite: | PDOC00150; | ||
| PDB: |
|
||
| Cath: | 1.10.1040.10; 1.10.1040.50; 1.10.12.10; 1.10.287.2460; 1.10.287.3850; 1.20.5.30; 1.20.5.3020; 3.30.160.260; 3.30.300.220; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.17 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.17 |
| KEGG Enzyme Link: | KEGG4.2.1.17 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.17 |
| ExPASy Enzyme Link: | ExPASy4.2.1.17 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.17 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.17 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.17 |
| RHEA:34863 | 2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:4]-[*:5].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bacterial phenylalanine and phenylacetate catabolic pathway revealed. | Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G | 2010 Aug 10 | 20660314 |
| RHEA:20724 | a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[OH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Domains of the tetrafunctional protein acting in glyoxysomal fatty acid beta-oxidation. Demonstration of epimerase and isomerase activities on a peptide lacking hydratase activity. | Preisig-Müller R, Gühnemann-Schäfer K, Kindl H | 1994 Aug 12 | 8051146 |
| Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. | Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N | 2015 Oct | 26251176 |
| Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis. | Johansson P, Castell A, Jones TA, Bäckbro K | 2006 Oct | 16963641 |
| Identification of a rice RNA- and microtubule-binding protein as the multifunctional protein, a peroxisomal enzyme involved in the beta -oxidation of fatty acids. | Chuong SD, Mullen RT, Muench DG | 2002 Jan 25 | 11706039 |
| RHEA:16105 | a (3S)-hydroxyacyl-CoA = a (2E)-enoyl CoA + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:4]-[*:5].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Domains of the tetrafunctional protein acting in glyoxysomal fatty acid beta-oxidation. Demonstration of epimerase and isomerase activities on a peptide lacking hydratase activity. | Preisig-Müller R, Gühnemann-Schäfer K, Kindl H | 1994 Aug 12 | 8051146 |
| Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. | Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N | 2015 Oct | 26251176 |
| Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis. | Johansson P, Castell A, Jones TA, Bäckbro K | 2006 Oct | 16963641 |
| Identification of a rice RNA- and microtubule-binding protein as the multifunctional protein, a peroxisomal enzyme involved in the beta -oxidation of fatty acids. | Chuong SD, Mullen RT, Muench DG | 2002 Jan 25 | 11706039 |