EC number:4.2.1.2

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.2
Description:Fumarate hydratase.
Alternative Name: Fumarase.
Prosite: PDOC00147;
PDB:
PDBScop
1TJ7 8030108; 8042487; 8030108; 8042487;
1TJW 8027870; 8040249; 8027870; 8040249; 8027870; 8040249; 8027870; 8040249;
1TJV 8027870; 8040249; 8027870; 8040249; 8027870; 8040249; 8027870; 8040249;
1TJU 8027870; 8040249; 8027870; 8040249; 8027870; 8040249; 8027870; 8040249;
1HY1 8027870; 8040249; 8027870; 8040249; 8027870; 8040249; 8027870; 8040249;
 » show all
Cath: 1.10.275.10; 1.10.40.30; 1.20.200.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.2
BRENDA Enzyme Link: BRENDA 4.2.1.2
KEGG Enzyme Link: KEGG4.2.1.2
BioCyc Enzyme Link: BioCyc 4.2.1.2
ExPASy Enzyme Link: ExPASy4.2.1.2
EC2PDB Enzyme Link: EC2PDB 4.2.1.2
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.2
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.2
IntEnz Enzyme Link: IntEnz 4.2.1.2
MEDLINE Enzyme Link: MEDLINE 4.2.1.2

EC number:4.2.1.2

MSA:

4.2.1.2;
Phylogenetic Tree:

4.2.1.2;
Uniprot:
M-CSA:
RHEA:12460 (S)-malate = fumarate + H2O
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[OH2;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.Sévin DC, Fuhrer T, Zamboni N, Sauer U2017 Feb27941785
THE PREPARATION AND CHARACTERIZATION OF FUMARASE FROM SWINE HEART MUSCLE.KANAREK L, HILL RL1964 Dec14247669