EC number:4.2.1.28
| ID: | 4.2.1.28 |
|---|---|
| Description: | Propanediol dehydratase. |
| Cath: | 1.10.1510.20; 3.20.20.350; 3.40.50.10150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.28 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.28 |
| KEGG Enzyme Link: | KEGG4.2.1.28 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.28 |
| ExPASy Enzyme Link: | ExPASy4.2.1.28 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.28 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.28 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.28 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.28 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.28 |
| RHEA:14569 | propane-1,2-diol = 1-propanal + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[OH;+0:5]>>[*:1]-[CH2;+0:2]-[CH;+0:4]=[O;H0;+0:5].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Propanediol utilization genes (pdu) of Salmonella typhimurium: three genes for the propanediol dehydratase. | Bobik TA, Xu Y, Jeter RM, Otto KE, Roth JR | 1997 Nov | 9352910 |
| Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases. | Forage RG, Foster MA | 1982 Feb | 7035429 |
| Coenzyme B 12 -dependent propanediol dehydratase systems. Ternary complex between apoenzyme, coenzyme, and substrate analog. | Toraya T, Fukui S | 1972 Oct 12 | 4635826 |
| Diol metabolism and diol dehydratase in Clostridium glycolicum. | Hartmanis MG, Stadtman TC | 1986 Feb 15 | 2936306 |
| Catalytic roles of the metal ion in the substrate-binding site of coenzyme B12-dependent diol dehydratase. | Kamachi T, Doitomi K, Takahata M, Toraya T, Yoshizawa K | 2011 Apr 4 | 21388166 |
| Histidine-alpha143 assists 1,2-hydroxyl group migration and protects radical intermediates in coenzyme B12-dependent diol dehydratase. | Kinoshita K, Kawata M, Ogura K, Yamasaki A, Watanabe T, Komoto N, Hieda N, Yamanishi M, Tobimatsu T, Toraya T | 2008 Mar 11 | 18260646 |
| Radical catalysis of B12 enzymes: structure, mechanism, inactivation, and reactivation of diol and glycerol dehydratases. | Toraya T | 2000 Jan 20 | 10949584 |
| How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex. | Masuda J, Shibata N, Morimoto Y, Toraya T, Yasuoka N | 2000 Jul 15 | 10903944 |