EC number:4.2.1.3

Enzyme

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     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.1 Hydro-lyases
ID:4.2.1.3
Description:Aconitate hydratase.
Alternative Name: Citrate(isocitrate) hydro-lyase.
Citrate hydro-lyase.
Cis-aconitase.
Aconitase.
Prosite: PDOC00423;
PDB:
PDBScop
1L5J 8028704; 8028708; 8028710; 8041083; 8041087; 8041089; 8028704; 8028708; 8028710; 8041083; 8041087; 8041089;
2B3Y 8025216; 8025218; 8037595; 8037597; 8025216; 8025218; 8037595; 8037597;
2B3X 8025216; 8025218; 8037595; 8037597;
8ACN 8020684; 8031522; 8033064; 8043900;
1NIT 8020684; 8031522; 8033064; 8043900;
 » show all
Cath: 1.10.1440.20; 1.10.4100.10; 3.20.19.10; 3.30.1330.120; 3.30.499.10; 3.30.499.20; 3.40.1060.10; 1.25.40.310; 3.10.129.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.1.3
BRENDA Enzyme Link: BRENDA 4.2.1.3
KEGG Enzyme Link: KEGG4.2.1.3
BioCyc Enzyme Link: BioCyc 4.2.1.3
ExPASy Enzyme Link: ExPASy4.2.1.3
EC2PDB Enzyme Link: EC2PDB 4.2.1.3
ExplorEnz Enzyme Link: ExplorEnz 4.2.1.3
PRIAM enzyme-specific profiles Link: PRIAM 4.2.1.3
IntEnz Enzyme Link: IntEnz 4.2.1.3
MEDLINE Enzyme Link: MEDLINE 4.2.1.3

EC number:4.2.1.3

MSA:

4.2.1.3;
Phylogenetic Tree:

4.2.1.3;
Uniprot:
M-CSA:
RHEA:10336 citrate = isocitrate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH2;+0:5]-[*:6]>>[*:1]-[CH;+0:2](-[*:3])-[CH;+0:5](-[*:6])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structures of aconitase with trans-aconitate and nitrocitrate bound.Lauble H, Kennedy MC, Beinert H, Stout CD1994 Apr 88151704
The purification of aconitase.MORRISON JF1954 Jan13126098