EnzyMine

Download

EC Tree

4. Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

ID:

4.2.1.33

Description:

3-isopropylmalate dehydratase.

Alternative Name:

Isopropylmalate isomerase.
Alpha-IPM isomerase.
3-isopropylmalate hydro-lyase.
(2R,3S)-3-isopropylmalate hydro-lyase.

Prosite:

PDOC00423;

PDB:

PDB	Scop

Cath:

3.20.19.10; 3.30.499.10; 3.30.499.20;

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 4.2.1.33
BRENDA Enzyme Link:	BRENDA 4.2.1.33
KEGG Enzyme Link:	KEGG4.2.1.33
BioCyc Enzyme Link:	BioCyc 4.2.1.33
ExPASy Enzyme Link:	ExPASy4.2.1.33
EC2PDB Enzyme Link:	EC2PDB 4.2.1.33
ExplorEnz Enzyme Link:	ExplorEnz 4.2.1.33
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.1.33
IntEnz Enzyme Link:	IntEnz 4.2.1.33
MEDLINE Enzyme Link:	MEDLINE 4.2.1.33

RHEA:32287	(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[CH;+0:4](-[:5])-[OH;+0:6]>>[:1]-[C;H0;+0:2](-[:3])(-[OH;+0:6])-[CH2;+0:4]-[:5]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine.	Cole FE, Kalyanpur MG, Stevens CM	1973 Aug 14	4270046
Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes.	Jang S, Imlay JA	2007 Jan 12	17102132
THE BIOSYNTHESIS OF LEUCINE. II. THE ENZYMIC ISOMERIZATION OF BETA-CARBOXY-BETA-HYDROXYISOCAPROATE AND ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE.	GROSS SR, BURNS RO, UMBARGER HE	1963 Sep-Oct	14087357
Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii.	Drevland RM, Waheed A, Graham DE	2007 Jun	17449626