EC number:4.2.1.79
| ID: | 4.2.1.79 |
|---|---|
| Description: | 2-methylcitrate dehydratase. |
| Alternative Name: |
2-methylcitrate hydro-lyase. 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. |
| Cath: | 1.10.4100.10; 3.30.1330.120; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.79 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.79 |
| KEGG Enzyme Link: | KEGG4.2.1.79 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.79 |
| ExPASy Enzyme Link: | ExPASy4.2.1.79 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.79 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.79 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.79 |
| RHEA:17725 | (2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:4](-[*:5])(-[*:6])-[OH;+0:7]>>[*:1]-[C;H0;+0:2](-[*:3])=[C;H0;+0:4](-[*:5])-[*:6].[OH2;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. | Horswill AR, Escalante-Semerena JC | 2001 Apr 17 | 11294638 |
| Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase. | Brock M, Maerker C, Schütz A, Völker U, Buckel W | 2002 Dec | 12473114 |
| AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. | Blank L, Green J, Guest JR | 2002 Jan | 11782506 |
| Subcellular localization of the methylcitric-acid-cycle enzymes in propionate metabolism of Yarrowia lipolytica. | Uchiyama H, Ando M, Toyonaka Y, Tabuchi T | 1982 Jul | 7117251 |
| Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. | Muñoz-Elías EJ, Upton AM, Cherian J, McKinney JD | 2006 Jun | 16689789 |