EC number:4.2.1.84
| ID: | 4.2.1.84 |
|---|---|
| Description: | Nitrile hydratase. |
| Alternative Name: |
Nitrile hydro-lyase. Nitrilase. |
| Cath: | 1.10.472.20; 3.60.110.10; 3.90.330.10; 2.30.30.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.1.84 |
| BRENDA Enzyme Link: | BRENDA 4.2.1.84 |
| KEGG Enzyme Link: | KEGG4.2.1.84 |
| BioCyc Enzyme Link: | BioCyc 4.2.1.84 |
| ExPASy Enzyme Link: | ExPASy4.2.1.84 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.1.84 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.1.84 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.1.84 |
| IntEnz Enzyme Link: | IntEnz 4.2.1.84 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.1.84 |
| RHEA:12673 | an aliphatic amide = a nitrile + H2O |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[NH2;+0:3])=[O;H0;+0:4]>>[*:1]-[C;H0;+0:2]#[N;H0;+0:3].[OH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Full reaction mechanism of nitrile hydratase: a cyclic intermediate and an unexpected disulfide switch. | Hopmann KH | 2014 Mar 17 | 24597943 |
| The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile. | Martinez S, Wu R, Sanishvili R, Liu D, Holz R | 2014 Jan 29 | 24383915 |
| Thermal equilibrium of two conformations in photosensitive nitrile hydratase probed by the FTIR band of nitric oxide bound to the non-heme iron center. | Suzuki H, Nojiri M, Kamiya N, Noguchi T | 2004 Jul | 15269247 |