Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.120
Description:(-)-beta-pinene synthase.
Alternative Name: Beta-geraniolene synthase.
(-)-(1S,5S)-pinene synthase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.120
BRENDA Enzyme Link: BRENDA 4.2.3.120
KEGG Enzyme Link: KEGG4.2.3.120
BioCyc Enzyme Link: BioCyc 4.2.3.120
ExPASy Enzyme Link: ExPASy4.2.3.120
EC2PDB Enzyme Link: EC2PDB 4.2.3.120
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.120
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.120
IntEnz Enzyme Link: IntEnz 4.2.3.120
MEDLINE Enzyme Link: MEDLINE 4.2.3.120
MSA:

4.2.3.120;

Phylogenetic Tree:

4.2.3.120;

Uniprot:
M-CSA:
RHEA:25496 (2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5]-[*:6]-[C;H0;+0:7](-[CH3;+0:8])=[CH;+0:9]-[CH2;+0:10]-[O;H0;+0:11]-[*:12]>>[*:1]-[C;H0;+0:2]1(-[*:3])-[CH;+0:9]2-[CH2;+0:10]-[CH;+0:4]-1-[*:5]-[*:6]-[C;H0;+0:7]-2=[CH2;+0:8].[*:12]-[OH;+0:11]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.Bohlmann J, Steele CL, Croteau R1997 Aug 299268308
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R1999 Aug 1510441373
Stereochemistry of the proton elimination in the formation of (+)- and (-)-alpha-pinene by monoterpene cyclases from sage (Salvia officinalis).Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R1994 Feb 18109979
Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents.Savage TJ, Ichii H, Hume SD, Little DB, Croteau R1995 Jul 107625832
Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene.Croteau R, Satterwhite DM, Cane DE, Chang CC1988 Jul 253392006
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.Croteau R, Satterwhite DM1989 Sep 152768265
Characterization of the constitutive and wound-inducible monoterpene cyclases of grand fir (Abies grandis).Gijzen M, Lewinsohn E, Croteau R1991 Sep1898071
Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE.Lewinsohn E, Gijzen M, Croteau R1992 Feb 141731633
Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis.Hyatt DC, Croteau R2005 Jul 1515978541
Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce.McKay SA, Hunter WL, Godard KA, Wang SX, Martin DM, Bohlmann J, Plant AL2003 Sep12970502
Cloning and functional characterization of a beta-pinene synthase from Artemisia annua that shows a circadian pattern of expression.Lu S, Xu R, Jia JW, Pang J, Matsuda SP, Chen XY2002 Sep12226526
Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers.Phillips MA, Savage TJ, Croteau R1999 Dec 110562434