Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.121
Description:(+)-alpha-pinene synthase.
Alternative Name: (+)-alpha-pinene cyclase.
Cath: 1.10.600.10; 1.50.10.130;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.121
BRENDA Enzyme Link: BRENDA 4.2.3.121
KEGG Enzyme Link: KEGG4.2.3.121
BioCyc Enzyme Link: BioCyc 4.2.3.121
ExPASy Enzyme Link: ExPASy4.2.3.121
EC2PDB Enzyme Link: EC2PDB 4.2.3.121
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.121
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.121
IntEnz Enzyme Link: IntEnz 4.2.3.121
MEDLINE Enzyme Link: MEDLINE 4.2.3.121
MSA:

4.2.3.121;

Phylogenetic Tree:

4.2.3.121;

Uniprot:
M-CSA:
RHEA:32575 (2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5]-[CH2;+0:6]-[*:7]=[*:8]-[CH2;+0:9]-[O;H0;+0:10]-[*:11]>>[*:1]-[C;H0;+0:2]1(-[*:3])-[CH;+0:6]2-[*:7]=[*:8]-[CH2;+0:9]-[CH;+0:4]-1-[*:5]-2.[*:11]-[OH;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase.Wise ML, Savage TJ, Katahira E, Croteau R1998 Jun 129614092
Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis).Wagschal KC, Pyun HJ, Coates RM, Croteau R1994 Feb 18109978
Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration.Gambliel H, Croteau R1984 Jan 256693393
Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-alpha-pinene and (-)-beta-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate.Croteau RB, Wheeler CJ, Cane DE, Ebert R, Ha HJ1987 Aug 253314988
Stereochemistry of the proton elimination in the formation of (+)- and (-)-alpha-pinene by monoterpene cyclases from sage (Salvia officinalis).Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R1994 Feb 18109979
Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene.Croteau R, Satterwhite DM, Cane DE, Chang CC1988 Jul 253392006
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.Croteau R, Satterwhite DM1989 Sep 152768265
cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis.Phillips MA, Wildung MR, Williams DC, Hyatt DC, Croteau R2003 Mar 1512623076
Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers.Phillips MA, Savage TJ, Croteau R1999 Dec 110562434