Title | Authors | Date | PubMed ID |
Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans. | Kudo F, Yamauchi N, Suzuki R, Kakinuma K | 1997 May | 9207913 |
Roles of a 20 kDa protein associated with a carbocycle-forming enzyme involved in aminoglycoside biosynthesis in primary and secondary metabolism. | Tamegai H, Sawada H, Nango E, Aoki R, Hirakawa H, Iino T, Eguchi T | 2010 | 20530911 |
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+. | Nango E, Kumasaka T, Hirayama T, Tanaka N, Eguchi T | 2008 Feb 1 | 17879343 |
Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans. | Thuy ML, Kharel MK, Lamichhane R, Lee HC, Suh JW, Liou K, Sohng JK | 2005 Apr | 15928851 |
Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. | Huang Z, Kakinuma K, Eguchi T | 2005 Apr | 15788164 |
Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans. | Tamegai H, Nango E, Koike-Takeshita A, Kudo F, Kakinuma K | 2002 Jul | 12224638 |
Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase. | Kudo F, Tamegai H, Fujiwara T, Tagami U, Hirayama K, Kakinuma K | 1999 Jun | 10470681 |
Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocyclization enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. | Kudo F, Hosomi Y, Tamegai H, Kakinuma K | 1999 Feb | 10344560 |