Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.131
Description:Miltiradiene synthase.
Cath: 1.10.600.10; 1.50.10.130; 1.50.10.160;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.131
BRENDA Enzyme Link: BRENDA 4.2.3.131
KEGG Enzyme Link: KEGG4.2.3.131
BioCyc Enzyme Link: BioCyc 4.2.3.131
ExPASy Enzyme Link: ExPASy4.2.3.131
EC2PDB Enzyme Link: EC2PDB 4.2.3.131
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.131
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.131
IntEnz Enzyme Link: IntEnz 4.2.3.131
MEDLINE Enzyme Link: MEDLINE 4.2.3.131
MSA:

4.2.3.131;

Phylogenetic Tree:

4.2.3.131;

Uniprot:
M-CSA:
RHEA:33983 (+)-copalyl diphosphate = diphosphate + miltiradiene
RULE(radius=1) [*:1]-[CH2;+0:2]-[C;H0;+0:3](=[CH2;+0:4])-[CH;+0:5](-[*:6])-[CH2;+0:7]-[*:8]-[*:9](-[CH3;+0:10])=[*:11]-[CH2;+0:12]-[O;H0;+0:13]-[*:14]>>[*:1]-[CH2;+0:2]-[C;H0;+0:7]1=[C;H0;+0:5](-[*:6])-[CH2;+0:12]-[*:11]=[*:9](-[CH;+0:10](-[CH3;+0:3])-[CH3;+0:4])-[*:8]-1.[*:14]-[OH;+0:13]
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References

TitleAuthorsDatePubMed ID
Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes.Brückner K, Božić D, Manzano D, Papaefthimiou D, Pateraki I, Scheler U, Ferrer A, de Vos RC, Kanellis AK, Tissier A2014 May24569175
A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, Yang B, Peters RJ2009 Nov 1919905026
Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii.Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, Natsume M, Nozaki H, Kawaide H2011 Dec 1622027823