EC number:4.2.3.143

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.143
Description:Kunzeaol synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.143
BRENDA Enzyme Link: BRENDA 4.2.3.143
KEGG Enzyme Link: KEGG4.2.3.143
BioCyc Enzyme Link: BioCyc 4.2.3.143
ExPASy Enzyme Link: ExPASy4.2.3.143
EC2PDB Enzyme Link: EC2PDB 4.2.3.143
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.143
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.143
IntEnz Enzyme Link: IntEnz 4.2.3.143
MEDLINE Enzyme Link: MEDLINE 4.2.3.143

EC number:4.2.3.143

MSA:

4.2.3.143;
Phylogenetic Tree:

4.2.3.143;
Uniprot:
M-CSA:
RHEA:36063 (2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol
RULE(radius=1) ([*:1]-[CH2;+0:2]-[O;H0;+0:3]-[P;H0;+0:4](-[*:5])(=[*:6])-[*:7].[*:8]-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[*:12]).[OH2;+0:13]>>[*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:9](-[*:8])-[CH;+0:10](-[*:11])-[*:12].[*:5]-[P;H0;+0:4](=[*:6])(-[*:7])-[OH;+0:13]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin.Pickel B, Drew DP, Manczak T, Weitzel C, Simonsen HT, Ro DK2012 Dec 122938155