EC number:4.2.3.156
| ID: | 4.2.3.156 |
|---|---|
| Description: | Hydroxysqualene synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.156 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.156 |
| KEGG Enzyme Link: | KEGG4.2.3.156 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.156 |
| ExPASy Enzyme Link: | ExPASy4.2.3.156 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.156 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.156 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.156 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.156 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.156 |
EC number:4.2.3.156
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:47984 | H2O + presqualene diphosphate = diphosphate + hydroxysqualene |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[CH;+0:3](-[CH2;+0:4]-[O;H0;+0:5]-[*:6])-[C;H0;+0:7]-1(-[CH3;+0:8])-[CH2;+0:9]-[*:10]-[CH;+0:11]=[C;H0;+0:12](-[CH3;+0:13])-[CH2;+0:14]-[*:15]-[CH;+0:16]=[C;H0;+0:17](-[CH3;+0:18])-[CH3;+0:19].[OH2;+0:20]>>[*:1]-[CH2;+0:2]-[CH;+0:3](-[OH;+0:20])-[CH;+0:7]=[C;H0;+0:9](-[CH3;+0:4])-[*:10]-[CH2;+0:11]-[CH;+0:12]=[C;H0;+0:14](-[CH3;+0:8])-[*:15]-[CH2;+0:16]-[CH;+0:17]=[C;H0;+0:19](-[CH3;+0:13])-[CH3;+0:18].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes. | Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD | 2015 | 26258173 |