EC number:4.2.3.159

Enzyme

Download
EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.159
Description:Tsukubadiene synthase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.159
BRENDA Enzyme Link: BRENDA 4.2.3.159
KEGG Enzyme Link: KEGG4.2.3.159
BioCyc Enzyme Link: BioCyc 4.2.3.159
ExPASy Enzyme Link: ExPASy4.2.3.159
EC2PDB Enzyme Link: EC2PDB 4.2.3.159
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.159
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.159
IntEnz Enzyme Link: IntEnz 4.2.3.159
MEDLINE Enzyme Link: MEDLINE 4.2.3.159

EC number:4.2.3.159

MSA:

4.2.3.159;
Phylogenetic Tree:

4.2.3.159;
Uniprot:
M-CSA:
RHEA:53624 all-trans-geranylgeranyl diphosphate = diphosphate + tsukubadiene
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[CH2;+0:4]-[CH;+0:5]=[C;H0;+0:6](-[CH3;+0:7])-[*:8]-[CH2;+0:9]-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[*:14]-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[*:18])=[CH;+0:19]-[CH2;+0:20]-[O;H0;+0:21]-[*:22]>>[*:1]-[C;H0;+0:2]12-[CH2;+0:19]-[CH2;+0:20]-[C;H0;+0:16](-[*:17])(-[*:18])-[CH;+0:15]-1-[*:14]-[CH;+0:13]=[C;H0;+0:11](-[*:12])-[CH2;+0:10]-[CH;+0:9]1-[*:8]-[CH2;+0:6]-[CH;+0:5](-[CH3;+0:7])-[C;H0;+0:4]-1=[CH;+0:3]-2.[*:22]-[OH;+0:21]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase.Rabe P, Rinkel J, Dolja E, Schmitz T, Nubbemeyer B, Luu TH, Dickschat JS2017 Mar 128146322
Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-ya K, Cane DE, Ikeda H2015 Jun25605043