EC number:4.2.3.163

Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.163
Description:(+)-corvol ether B synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.163
BRENDA Enzyme Link: BRENDA 4.2.3.163
KEGG Enzyme Link: KEGG4.2.3.163
BioCyc Enzyme Link: BioCyc 4.2.3.163
ExPASy Enzyme Link: ExPASy4.2.3.163
EC2PDB Enzyme Link: EC2PDB 4.2.3.163
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.163
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.163
IntEnz Enzyme Link: IntEnz 4.2.3.163
MEDLINE Enzyme Link: MEDLINE 4.2.3.163

EC number:4.2.3.163

MSA:

4.2.3.163;
Phylogenetic Tree:

4.2.3.163;
Uniprot:
M-CSA:
RHEA:53644 (2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8]-[CH2;+0:9]-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[*:13])=[CH;+0:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17].[OH2;+0:18]>>[*:1]-[CH;+0:2]1-[CH2;+0:14]-[CH2;+0:15]-[C;H0;+0:9]23-[*:8]-[C;H0;+0:6](-[*:7])(-[CH2;+0:5]-[*:4]-[CH;+0:3]-1-2)-[O;H0;+0:18]-[CH;+0:10]-3-[CH;+0:11](-[*:12])-[*:13].[*:17]-[OH;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structures and Biosynthesis of Corvol Ethers--Sesquiterpenes from the Actinomycete Kitasatospora setae.Rabe P, Pahirulzaman KA, Dickschat JS2015 May 1125809275
Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations.Rinkel J, Rabe P, Garbeva P, Dickschat JS2016 Oct 1727666571