Enzyme

Download
EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.18
Description:Abieta-7,13-diene synthase.
Alternative Name: Abietadiene synthase.
Abietadiene cyclase.
Cath: 1.10.600.10; 1.50.10.130; 1.50.10.160;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.18
BRENDA Enzyme Link: BRENDA 4.2.3.18
KEGG Enzyme Link: KEGG4.2.3.18
BioCyc Enzyme Link: BioCyc 4.2.3.18
ExPASy Enzyme Link: ExPASy4.2.3.18
EC2PDB Enzyme Link: EC2PDB 4.2.3.18
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.18
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.18
IntEnz Enzyme Link: IntEnz 4.2.3.18
MEDLINE Enzyme Link: MEDLINE 4.2.3.18
MSA:

4.2.3.18;

Phylogenetic Tree:

4.2.3.18;

Uniprot:
M-CSA:
RHEA:13873 (+)-copalyl diphosphate = abieta-7,13-diene + diphosphate
RULE(radius=1) ([*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:4](=[CH2;+0:5])-[CH2;+0:6]-[*:7].[*:8]-[O;H0;+0:9]-[CH2;+0:10]-[*:11]=[*:12]-[CH3;+0:13])>>[*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:10](-[*:11]=[*:12]-[CH;+0:13](-[CH3;+0:4])-[CH3;+0:5])=[CH;+0:6]-[*:7].[*:8]-[OH;+0:9]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases.Hall DE, Zerbe P, Jancsik S, Quesada AL, Dullat H, Madilao LL, Yuen M, Bohlmann J2013 Feb23370714
Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production.Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J2012 Apr 622337889
The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol.Keeling CI, Madilao LL, Zerbe P, Dullat HK, Bohlmann J2011 Jun 1721518766
A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.Wilderman PR, Peters RJ2007 Dec 2618052062
Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates.Ravn MM, Peters RJ, Coates RM, Croteau R2002 Jun 1912059223
Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate.Peters RJ, Croteau RB2002 Feb 1211827528
Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement.Peters RJ, Croteau RB2002 Jan 2211805316
Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites.Peters RJ, Ravn MM, Coates RM, Croteau RB2001 Sep 1911552804
Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme.Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau RB2000 Dec 1911112547