EnzyMine

Download

EC Tree

4. Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

ID:	4.2.3.194
Description:	(-)-drimenol synthase.
Alternative Name:	Farnesyl pyrophosphate:drimenol cyclase. Drimenol cyclase.

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 4.2.3.194
BRENDA Enzyme Link:	BRENDA 4.2.3.194
KEGG Enzyme Link:	KEGG4.2.3.194
BioCyc Enzyme Link:	BioCyc 4.2.3.194
ExPASy Enzyme Link:	ExPASy4.2.3.194
EC2PDB Enzyme Link:	EC2PDB 4.2.3.194
ExplorEnz Enzyme Link:	ExplorEnz 4.2.3.194
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.3.194
IntEnz Enzyme Link:	IntEnz 4.2.3.194
MEDLINE Enzyme Link:	MEDLINE 4.2.3.194

RHEA:28290	(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate
RULE(radius=1)	[:1]-[C;H0;+0:2](-[CH2;+0:3]-[:4]-[CH;+0:5]=[C;H0;+0:6](-[:7])-[:8]-[:9]-[CH;+0:10]=[C;H0;+0:11](-[:12])-[:13])=[CH;+0:14]-[:15]-[O;H0;+0:16]-[P;H0;+0:17](-[:18])(=[:19])-[:20].[OH2;+0:21]>>[:1]-[C;H0;+0:2]1=[CH;+0:3]-[:4]-[CH;+0:5]2-[C;H0;+0:6](-[:7])(-[:8]-[:9]-[CH2;+0:10]-[C;H0;+0:11]-2(-[:12])-[:13])-[CH;+0:14]-1-[:15]-[OH;+0:16].[:18]-[P;H0;+0:17](=[:19])(-[:20])-[OH;+0:21]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes.	Henquet MGL, Prota N, van der Hooft JJJ, Varbanova-Herde M, Hulzink RJM, de Vos M, Prins M, de Both MTJ, Franssen MCR, Bouwmeester H, Jongsma M	2017 Jun	28258968
Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).	Kwon M, Cochrane SA, Vederas JC, Ro DK	2014 Dec 20	25447532