EC number:4.2.3.22
| ID: | 4.2.3.22 |
|---|---|
| Description: | Germacradienol synthase. |
| Alternative Name: |
Germacradienol/germacrene-D synthase. |
| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.22 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.22 |
| KEGG Enzyme Link: | KEGG4.2.3.22 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.22 |
| ExPASy Enzyme Link: | ExPASy4.2.3.22 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.22 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.22 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.22 |
| RHEA:22436 | (2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate |
| RULE(radius=1) | ([*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[CH2;+0:5]-[O;H0;+0:6]-[*:7].[*:8]-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[*:12]).[OH2;+0:13]>>[*:1]-[CH;+0:2](-[*:3])-[CH;+0:4]=[CH;+0:5]-[CH;+0:9](-[*:8])-[C;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:13].[*:7]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. | Jiang J, He X, Cane DE | 2006 Jun 28 | 16787064 |
| Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis. | Cane DE, Watt RM | 2003 Feb 18 | 12556563 |
| Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries. | Lücker J, Bowen P, Bohlmann J | 2004 Oct | 15464152 |
| Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2). | He X, Cane DE | 2004 Mar 10 | 14995166 |
| PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. | Gust B, Challis GL, Fowler K, Kieser T, Chater KF | 2003 Feb 18 | 12563033 |