EC number:4.2.3.24
| ID: | 4.2.3.24 |
|---|---|
| Description: | Amorpha-4,11-diene synthase. |
| Alternative Name: |
Amorphadiene synthase. |
| Cath: | 1.10.600.10; 1.50.10.130; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.24 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.24 |
| KEGG Enzyme Link: | KEGG4.2.3.24 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.24 |
| ExPASy Enzyme Link: | ExPASy4.2.3.24 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.24 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.24 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.24 |
| RHEA:18325 | (2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[*:9]-[*:10]-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH3;+0:14])>>[*:1]-[CH;+0:2]1-[CH;+0:6](-[*:5])-[CH;+0:7](-[*:8])-[*:9]-[*:10]-[CH;+0:11]-1-[C;H0;+0:12](-[*:13])=[CH2;+0:14].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. | Picaud S, Mercke P, He X, Sterner O, Brodelius M, Cane DE, Brodelius PE | 2006 Apr 15 | 16143293 |
| Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. | Wallaart TE, Bouwmeester HJ, Hille J, Poppinga L, Maijers NC | 2001 Feb | 11289612 |
| Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis. | Chang YJ, Song SH, Park SH, Kim SU | 2000 Nov 15 | 11185551 |
| Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. | Mercke P, Bengtsson M, Bouwmeester HJ, Posthumus MA, Brodelius PE | 2000 Sep 15 | 11032404 |
| Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. | Bouwmeester HJ, Wallaart TE, Janssen MH, van Loo B, Jansen BJ, Posthumus MA, Schmidt CO, De Kraker JW, König WA, Franssen MC | 1999 Nov | 10626375 |