Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.37
Description:Epi-isozizaene synthase.
Cath: 1.10.600.10; 1.10.630.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.37
BRENDA Enzyme Link: BRENDA 4.2.3.37
KEGG Enzyme Link: KEGG4.2.3.37
BioCyc Enzyme Link: BioCyc 4.2.3.37
ExPASy Enzyme Link: ExPASy4.2.3.37
EC2PDB Enzyme Link: EC2PDB 4.2.3.37
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.37
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.37
IntEnz Enzyme Link: IntEnz 4.2.3.37
MEDLINE Enzyme Link: MEDLINE 4.2.3.37
MSA:

4.2.3.37;

Phylogenetic Tree:

4.2.3.37;

Uniprot:
M-CSA:
RHEA:25992 (2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5]-[*:6]-[C;H0;+0:7](-[CH3;+0:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[CH;+0:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[C;H0;+0:2]1(-[*:3])-[C;H0;+0:14](-[CH3;+0:15])=[C;H0;+0:12]2-[*:11]-[*:10]-[CH;+0:9](-[CH3;+0:13])-[C;H0;+0:7]-23-[*:6]-[*:5]-[CH;+0:4]-1-[CH2;+0:8]-3.[*:17]-[OH;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE2008 Mar 2818234666
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.Lin X, Hopson R, Cane DE2006 May 1016669656