EC number:4.2.3.42
| ID: | 4.2.3.42 |
|---|---|
| Description: | Aphidicolan-16-beta-ol synthase. |
| Alternative Name: |
ACS. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.42 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.42 |
| KEGG Enzyme Link: | KEGG4.2.3.42 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.42 |
| ExPASy Enzyme Link: | ExPASy4.2.3.42 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.42 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.42 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.42 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.42 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.42 |
| RHEA:26213 | 9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5](-[*:6])-[C;H0;+0:7](-[*:8])=[CH2;+0:9])=[CH;+0:10]-[CH2;+0:11]-[O;H0;+0:12]-[*:13].[OH2;+0:14]>>[*:1]-[C;H0;+0:2]1(-[OH;+0:14])-[*:3]-[*:4]-[C;H0;+0:5]2(-[*:6])-[CH2;+0:11]-[CH;+0:10]-1-[CH2;+0:9]-[CH;+0:7]-2-[*:8].[*:13]-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha. | Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H | 2004 Jan | 14745177 |
| Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin. | Oikawa H, Toyomasu T, Toshima H, Ohashi S, Kawaide H, Kamiya Y, Ohtsuka M, Shinoda S, Mitsuhashi W, Sassa T | 2001 May 30 | 11457369 |