EC number:4.2.3.56
| ID: | 4.2.3.56 |
|---|---|
| Description: | Gamma-humulene synthase. |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.56 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.56 |
| KEGG Enzyme Link: | KEGG4.2.3.56 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.56 |
| ExPASy Enzyme Link: | ExPASy4.2.3.56 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.56 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.56 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.56 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.56 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.56 |
| RHEA:25456 | (2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene |
| RULE(radius=1) | ([*:1]-[C;H0;+0:2](-[CH3;+0:3])=[CH;+0:4]-[CH2;+0:5]-[O;H0;+0:6]-[*:7].[*:8]-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[*:12])>>[*:1]-[C;H0;+0:2](=[CH2;+0:3])-[CH;+0:4]=[CH;+0:5]-[C;H0;+0:10](-[*:11])(-[*:12])-[CH2;+0:9]-[*:8].[*:7]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |
| Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase. | Little DB, Croteau RB | 2002 Jun 1 | 12051690 |
| RHEA:25460 | (2E,6E)-farnesyl diphosphate = diphosphate + sibirene |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[CH;+0:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[C;H0;+0:2]12-[*:3]-[*:4]-[C;H0;+0:5](-[CH;+0:6](-[*:7])-[*:8])=[CH;+0:15]-[CH;+0:14]-1-[C;H0;+0:12](=[CH2;+0:13])-[*:11]-[*:10]-[CH2;+0:9]-2.[*:17]-[OH;+0:16] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |
| RHEA:25464 | (2E,6E)-farnesyl diphosphate = diphosphate + longifolene |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[CH;+0:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[C;H0;+0:2]12-[*:3]-[*:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])(-[*:8])-[CH;+0:13]3-[CH;+0:12](-[*:11]-[*:10]-[CH;+0:9]-3-1)-[C;H0;+0:14]-2=[CH2;+0:15].[*:17]-[OH;+0:16] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |
| Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily. | Martin DM, Fäldt J, Bohlmann J | 2004 Aug | 15310829 |
| RHEA:25468 | (2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate |
| RULE(radius=1) | |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |
| RHEA:25472 | (2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[*:10]-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[*:14])>>[*:1]-[CH;+0:2]1-[CH;+0:6](-[*:5])-[C;H0;+0:7](-[*:8])=[CH;+0:9]-[*:10]-[CH2;+0:11]-[C;H0;+0:12]-1(-[*:13])-[*:14].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |
| RHEA:25476 | (2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[CH;+0:6]=[C;H0;+0:7](-[CH3;+0:8])-[*:9]-[*:10]-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[*:14])>>[*:1]-[CH;+0:2]1-[CH;+0:6](-[*:5])-[C;H0;+0:7](=[CH2;+0:8])-[*:9]-[*:10]-[CH2;+0:11]-[C;H0;+0:12]-1(-[*:13])-[*:14].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase. | Steele CL, Crock J, Bohlmann J, Croteau R | 1998 Jan 23 | 9442047 |