EC number:4.2.3.6
| ID: | 4.2.3.6 |
|---|---|
| Description: | Trichodiene synthase. |
| Alternative Name: |
Trichodiene synthetase. Sesquiterpene cyclase. |
| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.6 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.6 |
| KEGG Enzyme Link: | KEGG4.2.3.6 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.6 |
| ExPASy Enzyme Link: | ExPASy4.2.3.6 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.6 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.6 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.6 |
| RHEA:12052 | (2E,6E)-farnesyl diphosphate = diphosphate + trichodiene |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[*:9]-[*:10]-[CH;+0:11]=[C;H0;+0:12](-[CH3;+0:13])-[CH3;+0:14])>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:5])(-[CH3;+0:13])-[C;H0;+0:7]1(-[*:8])-[*:9]-[*:10]-[CH2;+0:11]-[C;H0;+0:12]-1=[CH2;+0:14].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pre-steady-state kinetic analysis of the trichodiene synthase reaction pathway. | Cane DE, Chiu HT, Liang PH, Anderson KS | 1997 Jul 8 | 9204880 |
| Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. | Hohn TM, Beremand PD | 1989 Jun 30 | 2777086 |
| Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate. | Cane DE, Pawlak JL, Horak RM | 1990 Jun 12 | 2386780 |
| Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. | Vedula LS, Rynkiewicz MJ, Pyun HJ, Coates RM, Cane DE, Christianson DW | 2005 Apr 26 | 15835903 |
| X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity. | Rynkiewicz MJ, Cane DE, Christianson DW | 2002 Feb 12 | 11827517 |
| Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. | Rynkiewicz MJ, Cane DE, Christianson DW | 2001 Nov 20 | 11698643 |