EC number:4.2.3.7
| ID: | 4.2.3.7 |
|---|---|
| Description: | Pentalenene synthase. |
| Alternative Name: |
Pentalenene synthetase. |
| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.7 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.7 |
| KEGG Enzyme Link: | KEGG4.2.3.7 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.7 |
| ExPASy Enzyme Link: | ExPASy4.2.3.7 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.7 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.7 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.7 |
| RHEA:18081 | (2E,6E)-farnesyl diphosphate = diphosphate + pentalenene |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH2;+0:8]-[CH2;+0:9]-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[*:13])=[CH;+0:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[CH;+0:2]1-[*:3]-[*:4]-[CH;+0:5]2-[C;H0;+0:6](-[*:7])=[CH;+0:8]-[CH;+0:9]3-[CH2;+0:10]-[C;H0;+0:11](-[*:12])(-[*:13])-[CH2;+0:15]-[C;H0;+0:14]-1-2-3.[*:17]-[OH;+0:16] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. | Lesburg CA, Zhai G, Cane DE, Christianson DW | 1997 Sep 19 | 9295272 |
| Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. | Zu L, Xu M, Lodewyk MW, Cane DE, Peters RJ, Tantillo DJ | 2012 Jul 18 | 22738258 |
| Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. | Cane DE, Abell C, Harrison PH, Hubbard BR, Kane CT, Lattman R, Oliver JS, Weiner SW | 1991 May 29 | 1678531 |
| A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. | Tetzlaff CN, You Z, Cane DE, Takamatsu S, Omura S, Ikeda H | 2006 May 16 | 16681390 |
| Theoretical studies on farnesyl cation cyclization: pathways to pentalenene. | Gutta P, Tantillo DJ | 2006 May 10 | 16669687 |
| Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis. | Seemann M, Zhai G, de Kraker JW, Paschall CM, Christianson DW, Cane DE | 2002 Jul 3 | 12083921 |