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4. Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

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UniProtKB Enzyme Link:	UniProtKB 4.2.3.75
BRENDA Enzyme Link:	BRENDA 4.2.3.75
KEGG Enzyme Link:	KEGG4.2.3.75
BioCyc Enzyme Link:	BioCyc 4.2.3.75
ExPASy Enzyme Link:	ExPASy4.2.3.75
EC2PDB Enzyme Link:	EC2PDB 4.2.3.75
ExplorEnz Enzyme Link:	ExplorEnz 4.2.3.75
PRIAM enzyme-specific profiles Link:	PRIAM 4.2.3.75
IntEnz Enzyme Link:	IntEnz 4.2.3.75
MEDLINE Enzyme Link:	MEDLINE 4.2.3.75

RHEA:12016	(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate
RULE(radius=1)	([:1]-[C;H0;+0:2](-[CH3;+0:3])=[CH;+0:4]-[CH2;+0:5]-[O;H0;+0:6]-[:7].[:8]-[CH;+0:9]=[C;H0;+0:10](-[:11])-[:12])>>[:1]-[C;H0;+0:2](=[CH2;+0:3])-[CH;+0:4]=[CH;+0:5]-[CH;+0:9](-[:8])-[CH;+0:10](-[:11])-[:12].[:7]-[OH;+0:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases.	Deguerry F, Pastore L, Wu S, Clark A, Chappell J, Schalk M	2006 Oct 15	16970904
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.	Jiang J, He X, Cane DE	2006 Jun 28	16787064
The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basil.	Iijima Y, Davidovich-Rikanati R, Fridman E, Gang DR, Bar E, Lewinsohn E, Pichersky E	2004 Nov	15516500
Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis.	Cane DE, Watt RM	2003 Feb 18	12556563