EC number:4.2.3.9
| ID: | 4.2.3.9 |
|---|---|
| Description: | Aristolochene synthase. |
| Alternative Name: |
Trans,trans-farnesyl diphosphate aristolochene-lyase. Sesquiterpene cyclase. |
| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.2.3.9 |
| BRENDA Enzyme Link: | BRENDA 4.2.3.9 |
| KEGG Enzyme Link: | KEGG4.2.3.9 |
| BioCyc Enzyme Link: | BioCyc 4.2.3.9 |
| ExPASy Enzyme Link: | ExPASy4.2.3.9 |
| EC2PDB Enzyme Link: | EC2PDB 4.2.3.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.9 |
| IntEnz Enzyme Link: | IntEnz 4.2.3.9 |
| MEDLINE Enzyme Link: | MEDLINE 4.2.3.9 |
| RHEA:19825 | (2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH3;+0:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[*:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[CH;+0:2]1-[CH2;+0:9]-[*:10]-[*:11]-[C;H0;+0:12]2=[*:14]-[CH2;+0:15]-[CH;+0:5](-[C;H0;+0:6](-[*:7])=[CH2;+0:8])-[*:4]-[C;H0;+0:3]-2-1-[CH3;+0:13].[*:17]-[OH;+0:16] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti. | Proctor RH, Hohn TM | 1993 Feb 25 | 8440737 |
| Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene. | Calvert MJ, Ashton PR, Allemann RK | 2002 Oct 2 | 12296728 |
| Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. | Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW | 2000 Aug 18 | 10825154 |
| Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase. | Cane DE, Kang I | 2000 Apr 15 | 10775423 |
| Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. | Starks CM, Back K, Chappell J, Noel JP | 1997 Sep 19 | 9295271 |