Enzyme

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EC Tree
     4. Lyases
        4.2 Carbon-oxygen lyases
            4.2.3 Acting on phosphates
ID:4.2.3.9
Description:Aristolochene synthase.
Alternative Name: Trans,trans-farnesyl diphosphate aristolochene-lyase.
Sesquiterpene cyclase.
Cath: 1.10.600.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.2.3.9
BRENDA Enzyme Link: BRENDA 4.2.3.9
KEGG Enzyme Link: KEGG4.2.3.9
BioCyc Enzyme Link: BioCyc 4.2.3.9
ExPASy Enzyme Link: ExPASy4.2.3.9
EC2PDB Enzyme Link: EC2PDB 4.2.3.9
ExplorEnz Enzyme Link: ExplorEnz 4.2.3.9
PRIAM enzyme-specific profiles Link: PRIAM 4.2.3.9
IntEnz Enzyme Link: IntEnz 4.2.3.9
MEDLINE Enzyme Link: MEDLINE 4.2.3.9
MSA:

4.2.3.9;

Phylogenetic Tree:

4.2.3.9;

Uniprot:
M-CSA:
RHEA:19825 (2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH3;+0:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[*:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[CH;+0:2]1-[CH2;+0:9]-[*:10]-[*:11]-[C;H0;+0:12]2=[*:14]-[CH2;+0:15]-[CH;+0:5](-[C;H0;+0:6](-[*:7])=[CH2;+0:8])-[*:4]-[C;H0;+0:3]-2-1-[CH3;+0:13].[*:17]-[OH;+0:16]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti.Proctor RH, Hohn TM1993 Feb 258440737
Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene.Calvert MJ, Ashton PR, Allemann RK2002 Oct 212296728
Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW2000 Aug 1810825154
Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase.Cane DE, Kang I2000 Apr 1510775423
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase.Starks CM, Back K, Chappell J, Noel JP1997 Sep 199295271