ID: | 4.2.3.9 |
---|---|
Description: | Aristolochene synthase. |
Alternative Name: |
Trans,trans-farnesyl diphosphate aristolochene-lyase. Sesquiterpene cyclase. |
Cath: | 1.10.600.10; |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 4.2.3.9 |
BRENDA Enzyme Link: | BRENDA 4.2.3.9 |
KEGG Enzyme Link: | KEGG4.2.3.9 |
BioCyc Enzyme Link: | BioCyc 4.2.3.9 |
ExPASy Enzyme Link: | ExPASy4.2.3.9 |
EC2PDB Enzyme Link: | EC2PDB 4.2.3.9 |
ExplorEnz Enzyme Link: | ExplorEnz 4.2.3.9 |
PRIAM enzyme-specific profiles Link: | PRIAM 4.2.3.9 |
IntEnz Enzyme Link: | IntEnz 4.2.3.9 |
MEDLINE Enzyme Link: | MEDLINE 4.2.3.9 |
RHEA:19825 | (2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate |
RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[CH3;+0:8])=[CH;+0:9]-[*:10]-[*:11]-[C;H0;+0:12](-[CH3;+0:13])=[*:14]-[CH2;+0:15]-[O;H0;+0:16]-[*:17]>>[*:1]-[CH;+0:2]1-[CH2;+0:9]-[*:10]-[*:11]-[C;H0;+0:12]2=[*:14]-[CH2;+0:15]-[CH;+0:5](-[C;H0;+0:6](-[*:7])=[CH2;+0:8])-[*:4]-[C;H0;+0:3]-2-1-[CH3;+0:13].[*:17]-[OH;+0:16] |
Reaction | ![]() |
Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti. | Proctor RH, Hohn TM | 1993 Feb 25 | 8440737 |
Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene. | Calvert MJ, Ashton PR, Allemann RK | 2002 Oct 2 | 12296728 |
Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. | Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW | 2000 Aug 18 | 10825154 |
Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase. | Cane DE, Kang I | 2000 Apr 15 | 10775423 |
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. | Starks CM, Back K, Chappell J, Noel JP | 1997 Sep 19 | 9295271 |