EC number:4.3.1.2
| ID: | 4.3.1.2 |
|---|---|
| Description: | Methylaspartate ammonia-lyase. |
| Alternative Name: |
Beta-methylaspartase. |
| Cath: | 3.20.20.120; 3.30.390.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.3.1.2 |
| BRENDA Enzyme Link: | BRENDA 4.3.1.2 |
| KEGG Enzyme Link: | KEGG4.3.1.2 |
| BioCyc Enzyme Link: | BioCyc 4.3.1.2 |
| ExPASy Enzyme Link: | ExPASy4.3.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 4.3.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.3.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.3.1.2 |
| IntEnz Enzyme Link: | IntEnz 4.3.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 4.3.1.2 |
| RHEA:12829 | (2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH;+0:4](-[*:5])-[NH2;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[NH3;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 3-Methylaspartate ammonia-lyase as a marker enzyme of the mesaconate pathway for (S)-glutamate fermentation in Enterobacteriaceae. | Kato Y, Asano Y | 1997 Dec | 9385136 |
| Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids. | Raj H, Szymański W, de Villiers J, Rozeboom HJ, Veetil VP, Reis CR, de Villiers M, Dekker FJ, de Wildeman S, Quax WJ, Thunnissen AM, Feringa BL, Janssen DB, Poelarends GJ | 2012 Apr 29 | 22614383 |
| Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans. | Raj H, Puthan Veetil V, Szymanski W, Dekker FJ, Quax WJ, Feringa BL, Janssen DB, Poelarends GJ | 2012 Apr | 22005738 |
| Alteration of the diastereoselectivity of 3-methylaspartate ammonia lyase by using structure-based mutagenesis. | Raj H, Weiner B, Veetil VP, Reis CR, Quax WJ, Janssen DB, Feringa BL, Poelarends GJ | 2009 Sep 4 | 19670200 |
| Mechanism of C-3 hydrogen exchange and the elimination of ammonia in the 3-methylaspartate ammonia-lyase reaction. | Botting NP, Gani D | 1992 Feb 11 | 1531295 |
| Cloning, sequencing, and expression in Escherichia coli of the Clostridium tetanomorphum gene encoding beta-methylaspartase and characterization of the recombinant protein. | Goda SK, Minton NP, Botting NP, Gani D | 1992 Nov 10 | 1420191 |