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4. Lyases

4.3 Carbon-nitrogen lyases

4.3.1 Ammonia-lyases

ID:

4.3.1.24

Description:

Phenylalanine ammonia-lyase.

Prosite:

PDOC00424;

PDB:

PDB	Scop

Cath:

1.10.274.20; 1.10.275.10; 1.20.200.10;

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UniProtKB Enzyme Link:	UniProtKB 4.3.1.24
BRENDA Enzyme Link:	BRENDA 4.3.1.24
KEGG Enzyme Link:	KEGG4.3.1.24
BioCyc Enzyme Link:	BioCyc 4.3.1.24
ExPASy Enzyme Link:	ExPASy4.3.1.24
EC2PDB Enzyme Link:	EC2PDB 4.3.1.24
ExplorEnz Enzyme Link:	ExplorEnz 4.3.1.24
PRIAM enzyme-specific profiles Link:	PRIAM 4.3.1.24
IntEnz Enzyme Link:	IntEnz 4.3.1.24
MEDLINE Enzyme Link:	MEDLINE 4.3.1.24

RHEA:21384	L-phenylalanine = NH4(+) + trans-cinnamate
RULE(radius=1)	[:1]-[CH;+0:2](-[NH2;+0:3])-[CH2;+0:4]-[:5]>>[:1]-[CH;+0:2]=[CH;+0:4]-[:5].[NH3;+0:3]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from Taxus chinensis.	Wybenga GG, Szymanski W, Wu B, Feringa BL, Janssen DB, Dijkstra BW	2014 May 20	24786474
A modern view of phenylalanine ammonia lyase.	MacDonald MJ, D'Cunha GB	2007 Jun	17612622
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.	Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP	2006 Dec	17185228
Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.	Calabrese JC, Jordan DB, Boodhoo A, Sariaslani S, Vannelli T	2004 Sep 14	15350127
The Arabidopsis phenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms.	Cochrane FC, Davin LB, Lewis NG	2004 Jun	15276452