EC number:4.3.2.2
| ID: | 4.3.2.2 | ||
|---|---|---|---|
| Description: | Adenylosuccinate lyase. | ||
| Alternative Name: |
Succino AMP-lyase. Adenylosuccinase. | ||
| Prosite: | PDOC00147; | ||
| PDB: |
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| Cath: | 1.10.275.10; 1.10.275.60; 1.10.40.30; 1.20.200.10; 1.20.5.3210; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.3.2.2 |
| BRENDA Enzyme Link: | BRENDA 4.3.2.2 |
| KEGG Enzyme Link: | KEGG4.3.2.2 |
| BioCyc Enzyme Link: | BioCyc 4.3.2.2 |
| ExPASy Enzyme Link: | ExPASy4.3.2.2 |
| EC2PDB Enzyme Link: | EC2PDB 4.3.2.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.3.2.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.3.2.2 |
| IntEnz Enzyme Link: | IntEnz 4.3.2.2 |
| MEDLINE Enzyme Link: | MEDLINE 4.3.2.2 |
| RHEA:23920 | (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[CH2;+0:3]-[*:4])-[NH;+0:5]-[*:6]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:6]-[NH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation. | Ray SP, Deaton MK, Capodagli GC, Calkins LA, Sawle L, Ghosh K, Patterson D, Pegan SD | 2012 Aug 21 | 22812634 |
| Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. | Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL | 2007 Jul 13 | 17531264 |
| Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. | Lee P, Colman RF | 2007 Feb | 16973378 |
| Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. | Segall ML, Colman RF | 2004 Jun 15 | 15182182 |
| Adenylosuccinate lyase from Artemia embryos. Purification and properties. | Pinto RM, Faraldo A, Fernández A, Canales J, Sillero A, Sillero MA | 1983 Oct 25 | 6630197 |
| Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum. | Bulusu V, Srinivasan B, Bopanna MP, Balaram H | 2009 Apr | 19111634 |
| Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens. | Sivendran S, Colman RF | 2008 Jul | 18469177 |
| Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. | He B, Smith JM, Zalkin H | 1992 Jan | 1729205 |
| RHEA:16853 | N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[CH2;+0:3]-[*:4])-[NH;+0:5]-[*:6]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:6]-[NH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation. | Ray SP, Deaton MK, Capodagli GC, Calkins LA, Sawle L, Ghosh K, Patterson D, Pegan SD | 2012 Aug 21 | 22812634 |
| Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. | Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL | 2007 Jul 13 | 17531264 |
| Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. | Lee P, Colman RF | 2007 Feb | 16973378 |
| Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. | Segall ML, Colman RF | 2004 Jun 15 | 15182182 |