EC number:4.3.2.5
| ID: | 4.3.2.5 |
|---|---|
| Description: | Peptidylamidoglycolate lyase. |
| Alternative Name: |
Alpha-hydroxyglycine amidating dealkylase. |
| Cath: | 2.120.10.30; 2.60.120.230; 2.60.120.310; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.3.2.5 |
| BRENDA Enzyme Link: | BRENDA 4.3.2.5 |
| KEGG Enzyme Link: | KEGG4.3.2.5 |
| BioCyc Enzyme Link: | BioCyc 4.3.2.5 |
| ExPASy Enzyme Link: | ExPASy4.3.2.5 |
| EC2PDB Enzyme Link: | EC2PDB 4.3.2.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.3.2.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.3.2.5 |
| IntEnz Enzyme Link: | IntEnz 4.3.2.5 |
| MEDLINE Enzyme Link: | MEDLINE 4.3.2.5 |
| RHEA:20924 | a [peptide]-C-terminal-2-hydroxyglycine = a [peptide]-C-terminal-amide + glyoxylate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[NH;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine alpha-amidating enzyme. | Bell J, Ash DE, Snyder LM, Kulathila R, Blackburn NJ, Merkler DJ | 1997 Dec 23 | 9405058 |
| A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation. | Katopodis AG, Ping D, May SW | 1990 Jul 3 | 2207061 |
| Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. | Han M, Park D, Vanderzalm PJ, Mains RE, Eipper BA, Taghert PH | 2004 Jul | 15198673 |