EC number:4.3.3.6
| ID: | 4.3.3.6 |
|---|---|
| Description: | Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing). |
| Cath: | 1.20.1090.10; 3.20.20.70; 3.40.50.880; 3.40.50.1970; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.3.3.6 |
| BRENDA Enzyme Link: | BRENDA 4.3.3.6 |
| KEGG Enzyme Link: | KEGG4.3.3.6 |
| BioCyc Enzyme Link: | BioCyc 4.3.3.6 |
| ExPASy Enzyme Link: | ExPASy4.3.3.6 |
| EC2PDB Enzyme Link: | EC2PDB 4.3.3.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.3.3.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.3.3.6 |
| IntEnz Enzyme Link: | IntEnz 4.3.3.6 |
| MEDLINE Enzyme Link: | MEDLINE 4.3.3.6 |
| RHEA:31507 | aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]-[O;H0;+0:6]-[CH2;+0:7]-[CH;+0:8](-[OH;+0:9])-[CH;+0:10](-[*:11])-[CH;+0:12](-[*:13])-[OH;+0:14].[*:15]=[P;H0;+0:16](-[OH;+0:17])(-[OH;+0:18])-[*:19]-[*:20]-[CH;+0:21](-[OH;+0:22])-[CH;+0:23]=[O;H0;+0:24]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:22].[*:5]-[OH;+0:6].[*:15]=[P;H0;+0:16](-[OH;+0:14])(-[OH;+0:9])-[*:19]-[*:20]-[c;H0;+0:21]1:[cH;+0:23]:[n;H0;+0:4]:[c;H0;+0:8](-[CH3;+0:7]):[c;H0;+0:10](-[*:11]):[c;H0;+0:12]:1-[*:13].[OH2;+0:18].[OH2;+0:24].[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis. | Wallner S, Neuwirth M, Flicker K, Tews I, Macheroux P | 2009 Mar 10 | 19152323 |
| 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase. | Hanes JW, Keresztes I, Begley TP | 2008 Jul | 18516049 |
| Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. | Hanes JW, Burns KE, Hilmey DG, Chatterjee A, Dorrestein PC, Begley TP | 2008 Mar 12 | 18271580 |
| Trapping of a chromophoric intermediate in the Pdx1-catalyzed biosynthesis of pyridoxal 5'-phosphate. | Hanes JW, Keresztes I, Begley TP | 2008 | 18260082 |
| Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate. | Raschle T, Arigoni D, Brunisholz R, Rechsteiner H, Amrhein N, Fitzpatrick TB | 2007 Mar 2 | 17189272 |
| Structure of a bacterial pyridoxal 5'-phosphate synthase complex. | Strohmeier M, Raschle T, Mazurkiewicz J, Rippe K, Sinning I, Fitzpatrick TB, Tews I | 2006 Dec 19 | 17159152 |
| On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis. | Raschle T, Amrhein N, Fitzpatrick TB | 2005 Sep 16 | 16030023 |
| Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. | Burns KE, Xiang Y, Kinsland CL, McLafferty FW, Begley TP | 2005 Mar 23 | 15771487 |