Enzyme

Download
EC Tree
     4. Lyases
        4.4 Carbon-sulfur lyases
            4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
ID:4.4.1.11
Description:Methionine gamma-lyase.
Alternative Name: Methionine lyase.
L-methioninase.
Prosite: PDOC00677;
PDB:
PDBScop
Cath: 3.40.640.10; 3.90.1150.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.4.1.11
BRENDA Enzyme Link: BRENDA 4.4.1.11
KEGG Enzyme Link: KEGG4.4.1.11
BioCyc Enzyme Link: BioCyc 4.4.1.11
ExPASy Enzyme Link: ExPASy4.4.1.11
EC2PDB Enzyme Link: EC2PDB 4.4.1.11
ExplorEnz Enzyme Link: ExplorEnz 4.4.1.11
PRIAM enzyme-specific profiles Link: PRIAM 4.4.1.11
IntEnz Enzyme Link: IntEnz 4.4.1.11
MEDLINE Enzyme Link: MEDLINE 4.4.1.11
MSA:

4.4.1.11;

Phylogenetic Tree:

4.4.1.11;

Uniprot:
M-CSA:
RHEA:23800 H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)
RULE(radius=1) [*:1]-[CH;+0:2](-[NH2;+0:3])-[*:4]-[CH2;+0:5]-[S;H0;+0:6]-[*:7].[OH2;+0:8]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:8])-[*:4]-[CH3;+0:5].[*:7]-[SH;+0:6].[NH3;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification of bacterial L-methionine gamma-lyase.Nakayama T, Esaki N, Sugie K, Beresov TT, Tanaka H, Soda K1984 May 16742420
The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida.Fukumoto M, Kudou D, Murano S, Shiba T, Sato D, Tamura T, Harada S, Inagaki K201222785484
High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola.Fukamachi H, Nakano Y, Okano S, Shibata Y, Abiko Y, Yamashita Y2005 May 2715845368
3-Chloro-DL-alanine resistance by L-methionine-alpha-deamino-gamma-mercaptomethane-lyase activity.Yoshimura M, Nakano Y, Fukamachi H, Koga T2002 Jul 1712123816
Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2 Dias B, Weimer B1998 Sep9726878
Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes.Kreis W, Hession C1973 Aug4720797
Crystal structure of the external aldimine of Citrobacter freundii methionine γ-lyase with glycine provides insight in mechanisms of two stages of physiological reaction and isotope exchange of α- and β-protons of competitive inhibitors.Revtovich SV, Faleev NG, Morozova EA, Anufrieva NV, Nikulin AD, Demidkina TV2014 Jun24463191
Kinetic and spectral parameters of interaction of Citrobacter freundii methionine γ-lyase with amino acids.Morozova EA, Bazhulina NP, Anufrieva NV, Mamaeva DV, Tkachev YV, Streltsov SA, Timofeev VP, Faleev NG, Demidkina TV2010 Oct21166645
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.Goyer A, Collakova E, Shachar-Hill Y, Hanson AD2007 Feb17169919
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.Rébeillé F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S2006 Oct 1717030798
Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis.Yoshimura M, Nakano Y, Yamashita Y, Oho T, Saito T, Koga T2000 Dec11083813