EC number:4.4.1.13

Enzyme

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     4. Lyases
        4.4 Carbon-sulfur lyases
            4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
ID:4.4.1.13
Description:Cysteine-S-conjugate beta-lyase.
Alternative Name: S-alkylcysteine lyase.
S-alkylcysteinase.
S-alkyl-L-cysteine sulfoxide lyase.
S-alkyl-L-cysteine lyase.
L-cysteine-S-conjugate thiol-lyase (deaminating).
Cystine lyase.
Cystathionine beta-lyase.
Alkylcysteine lyase.
Alkyl cysteine lyase.
Cath: 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.4.1.13
BRENDA Enzyme Link: BRENDA 4.4.1.13
KEGG Enzyme Link: KEGG4.4.1.13
BioCyc Enzyme Link: BioCyc 4.4.1.13
ExPASy Enzyme Link: ExPASy4.4.1.13
EC2PDB Enzyme Link: EC2PDB 4.4.1.13
ExplorEnz Enzyme Link: ExplorEnz 4.4.1.13
PRIAM enzyme-specific profiles Link: PRIAM 4.4.1.13
IntEnz Enzyme Link: IntEnz 4.4.1.13
MEDLINE Enzyme Link: MEDLINE 4.4.1.13

EC number:4.4.1.13

MSA:

4.4.1.13;
Phylogenetic Tree:

4.4.1.13;
Uniprot:
M-CSA:
RHEA:18121 an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate
RULE(radius=1) [*:1]-[S;H0;+0:2]-[CH2;+0:3]-[CH;+0:4](-[*:5])-[NH2;+0:6].[OH2;+0:7]>>[*:5]-[C;H0;+0:4](-[CH3;+0:3])=[O;H0;+0:7].[*:1]-[SH;+0:2].[NH3;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.Tateishi M, Suzuki S, Shimizu H1978 Dec 25721818
Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.Cooper AJ, Krasnikov BF, Niatsetskaya ZV, Pinto JT, Callery PS, Villar MT, Artigues A, Bruschi SA2011 Jun20306345